The Art of Drug Synthesis

Author: Douglas S. Johnson
Publisher: John Wiley & Sons
ISBN: 9781118678466
Release Date: 2013-02-26
Genre: Science

The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed.

Innovative Drug Synthesis

Author: Jie Jack Li
Publisher: John Wiley & Sons
ISBN: 9781118820056
Release Date: 2015-12-14
Genre: MEDICAL

This book covers all aspects of the medicinal chemistry of the latest drugs, and the cutting-edge science associated with them. Following the editors’ 3 successful drug synthesis books, this provides expert analysis of the pros and cons of different synthetic routes and demystifies the process of modern drug discovery for practitioners and researchers. Summarizes for each drug: respective disease area, important properties and SAR (structure-activity relationship), and chemical synthesis routes / options Includes case studies in each chapter Illustrates how chemistry, biology, pharmacokinetics, and a host of disciplines come together to produce successful medicines Explains the advantages of process synthesis versus the synthetic route for drug discovery

An Introduction to Drug Synthesis

Author: Graham L. Patrick
Publisher: Oxford University Press, USA
ISBN: 9780198708438
Release Date: 2015-01
Genre: Science

'Introduction to Drug Synthesis' explores the central role played by organic synthesis in the process of drug design and development - from the generation of novel drug structures to the improved efficiency of large scale synthesis.

Medicinal Chemistry

Author: Gareth Thomas
Publisher: John Wiley & Sons
ISBN: 9781119965428
Release Date: 2011-09-20
Genre: Science

Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and multidisciplinary area of research. Building on the success of the First Edition, this edition has been completely revised and updated to include the latest developments in the field. Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles, assuming little in the way of prior knowledge. The book focuses on the chemical principles used for drug discovery and design covering physiology and biology where relevant. It opens with a broad overview of the subject with subsequent chapters examining topics in greater depth. From the reviews of the First Edition: "It contains a wealth of information in a compact form" ANGEWANDTE CHEMIE, INTERNATIONAL EDITION "Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market place." PHYSICAL SCIENCES AND EDUCATIONAL REVIEWS

Contemporary Drug Synthesis

Author: Jie Jack Li
Publisher: John Wiley & Sons
ISBN: 0471686735
Release Date: 2004-12-27
Genre: Science

An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Organic Chemistry

Author: Graham Patrick
Publisher: Oxford University Press
ISBN: 9780198759775
Release Date: 2017
Genre: Mathematics

Organic chemistry concerns the properties and synthesis of carbon-based molecules. Carbon atoms can concatenate into long chains and cyclic compounds, bonding with a variety of other elements, so the possible structures are almost limitless. Graham Patrick explores the world of organic chemistry and its wide applications.

Chemistry and Medicines

Author: James Ralph Hanson
Publisher: Royal Society of Chemistry
ISBN: 9780854046454
Release Date: 2006-01-01
Genre: Medical

Providing a general introduction to this fascinating subject, this book is aimed at those studying advanced undergraduate and postgraduate courses in medicinal chemistry.

An Introduction to Drug Design

Author: S. N. Pandeya
Publisher: New Age International
ISBN: 8122409431
Release Date: 1997
Genre: Drugs

The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.

Modern Drug Synthesis

Author: Jie Jack Li
Publisher: John Wiley & Sons
ISBN: 9781118701249
Release Date: 2013-03-27
Genre: Science

Following Contemporary Drug Synthesis and The Art of Drug Synthesis (Wiley, 2004 and 2007), two well-received works, is this new book that demystifies the process of modern drug discovery for practitioners and students. An enhanced introduction covers areas such as background, pharmacology, SAR, PK/PD, efficacy, and safety. Focusing on the advantages of process synthesis versus the discovery synthetic route, Modern Drug Synthesis features authoritative coverage by distinguished editors and authors (some chapter authors are the actual inventor of the drug) of twenty different drug molecules.

An Introduction to Medicinal Chemistry

Author: Graham Patrick
Publisher: Oxford University Press
ISBN: 9780198749691
Release Date: 2017
Genre: Pharmaceutical chemistry

For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?An Introduction to Medicinal Chemistry, sixthedition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Inaddition to covering the key principles of drug design and drug action, the text also discusses important current topics in medicinal chemistry. The subject is brought to life throughout by engaging case studies highlighting particular classes of drugs, and the stories behind their discovery and development.

An Introduction to Medicinal Chemistry

Author: Graham L. Patrick
Publisher: Oxford University Press, USA
ISBN: UOM:39015054260172
Release Date: 2001
Genre: Medical

NEW TO THIS EDITION Updated throughout with the latest descoveries Five new chapters covering * the molecular structure of receptors and the mechanisms of signal transduction *combinatorial synthesis * the role of computers in drug design * adrenergics * drug discovery and drug development

Fundamentals of Medicinal Chemistry

Author: Gareth Thomas
Publisher: John Wiley & Sons
ISBN: 9780470871690
Release Date: 2004-04-20
Genre: Science

Provides a concise introduction to the chemistry of therapeutically active compounds, written in a readable and accessible style. The title begins by reviewing the structures and nomenclature of the more common classes of naturally occurring compounds found in biological organisms. An overview of medicinal chemistry is followed by chapters covering the discovery and design of drugs, pharmacokinetics and drug metabolism, The book concludes with a chapter on organic synthesis, followed by a brief look at drug development from the research stage through to marketing the final product. The text assumes little in the way of prior biological knowledge. relevant biology is included through biological topics, examples and the Appendices. Incorporates summary sections, examples, applications and problems Each chapter contains an additional summary section and solutions to the questions are provided at the end of the text Invaluable for undergraduates studying within the chemical, pharmaceutical and life sciences.

The Organic Chemistry of Drug Synthesis

Author: Daniel Lednicer
Publisher: John Wiley & Sons
ISBN: 0471589594
Release Date: 1994-11-21
Genre: Science

Updated every five years, the series represents the optimal compromise between currency and a sufficient body of material for cohesive and comprehensive treatment in a monograph. Provides a quick yet thorough overview of the synthetic routines that have been used to access specific classes of therapeutic agents. Materials are organized by chemical class, and syntheses are taken back to available starting materials. Discusses disease state, rational for method of drug therapy, biological activities of each compound and preparation. Coverage also includes those generic pharmaceutical compounds not accorded clinical status. A glossary defines biological terms.

Drogen

Author: Johann Hari
Publisher: S. Fischer Verlag
ISBN: 9783104035680
Release Date: 2015-11-26
Genre: Fiction

»Hari vereint präzise Recherche mit einer zutiefst menschlichen Erzählung. Dieses Buch wird eine dringend notwendige Debatte auslösen.« Glenn Greenwald Der Krieg gegen die Drogen gilt inzwischen als gescheitert, der Handel mit Drogen ist ein blühendes Geschäft, alle Maßnahmen gegen den Konsum sind weitgehend erfolglos. Woran liegt das? Der britische Journalist Johann Hari begibt sich auf eine einzigartige Reise – von Brooklyn über Mexiko bis nach Deutschland – und erzählt die Geschichten derjenigen, deren Leben vom immerwährenden Kampf gegen Drogen geprägt ist: von Dealern, Süchtigen, Kartellmitgliedern, den Verlierern und Profiteuren. Mit seiner grandiosen literarischen Reportage schreibt Hari sowohl eine Geschichte des Krieges gegen Drogen als auch ein mitreißendes und streitbares Plädoyer zum Umdenken. »Hervorragender Journalismus, packend erzählt.« Naomi Klein »Phantastisch!« Noam Chomsky