Author: Thomas W. Clarkson
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
This document is the result of a conference on "Biological Monitoring of Metals" held in Rochester, June 2-6, 1986, organized jointly by the Environmental Health Sciences Center of the School of Medicine and Dentistry of the University of Rochester, NY, and the Scientific Committee on the Toxicology of Metals within the International Commission on Occupational Health (ICOH) at the Karolinska Institute and the National (Swedish) Institute of Environmental Medicine and the University of Umea, Sweden. The aim of the Conference was to define and evaluate the scientific basis for the biological monitoring of metals. The conference was co-sponsored by the World Health Organization through its International Program on Chemical Safety and received substantial encouragement and support from the Swedish Work Environmental Fund and the United States Environmental Protection Agency. This was the second conference organized jointly by the Scientific Committee on the Toxicology of Metals and The Toxicology Division of the University of Rochester. The previous joint conference was held in 1982 on the Reproductive and Developmental Toxicity of Metals. In addition, conferences have been organized by each group (see Appendices A and B). Several of these conferences are specially relevant to the topic of the current conference. These include the joint conference mentioned above and the conferences on dose-effect and dose-response relationship held in Tokyo in 1974 and on accumulation of metals held in Buenos Aires in 1972.
Author: Lucio G. Costa
Publisher: CRC Press
Release Date: 1998-05-18
Many chemical compounds present in workplace settings can produce a number of impairments in the human nervous system. As the situations in which neurotoxic agents have been recognized in exposed workers has grown, so has the importance of occupational neurotoxicology as a specialty. Addressing some of the most vital concerns in the field, Occupational Neurotoxicology discusses: Neurotoxic agents commonly encountered in the workplace Signs and symptoms of neurotoxicity and of the factors affecting neurotoxic effects Biological monitoring and the use of biomarkers Epidemiological methods and clinical approaches to occupational neurotoxicology The analysis of behavioral, electrophysiological, and imaging techniques in the diagnosis of neurotoxicity Occupational neurotoxicity in developing countries The evaluation and management of occupational illnesses due to neurotoxicity Occupational Neurotoxicology concisely covers important facts on the adverse effects of chemical, biological, and physical agents that can impair or alter the structure of the nervous system. Professionals and researchers in the fields of occupational medicine, toxicology, epidemiology, neurology, industrial hygiene, and psychology will all find relevant information on the health problems that can occur from exposure to neurotoxicants.
Author: Rita Cornelis
Publisher: John Wiley & Sons
Release Date: 2005-06-17
Written by an internationally recognized group of editors andcontributors, Handbook of Elemental Speciation, Volume 2provides a comprehensive, cross-disciplinary presentation of theanalytical techniques involved in speciation. Comprehensive coverage of key elements and compounds insitu Addresses the analysis and impact of these elements andcompounds, e.g. arsenic, lead, copper, iron, halogens, etc., in food, the environment, clinical and occupational health Detailed methodology and data are reported, as well asregulatory limits Includes general introduction on the impact in these keyareas
Author: Paul Mushak
Release Date: 2011
Genre: Business & Economics
The book presents a detailed assessment of the health science of lead and the human health risk assessment models for lead's human health impacts, followed by an account of various regulatory efforts in the United States and elsewhere to eliminate or reduce human toxic exposures to lead. The science of lead as presented here covers releases of lead into the environment, lead's movement through the environment to reach humans who are then exposed, and the spectrum of toxic effects, particularly low-level toxic effects, on the developing central nervous system of the very young child. The section on human health risk assessment deals with quantifying not only the dose-response relationships that underlie toxic responses to lead in sensitive populations but also with the likelihood of toxic responses vis-à-vis environmental lead at some level of exposure. This section includes a treatment of computer models of lead exposure, particularly those that use lead in whole blood as a key measure. Various models convert lead intake via various body compartments into measures of body lead burden. Such measures are then directly related to severity of injury. The final section of the book deals with past and present regulatory efforts to control lead releases into the human environment. Current control efforts present a mixed picture. The most problematic issue is the continued presence of lead paint in older housing and lead in soils of urban and mining industry communities. Comprehensive assessment of the three major facets of the public health problem of lead: the voluminous science, the risk assessment approaches, and approaches to controlling lead as a public health problem. Integration of the above three elements to provide a coherent whole Provides a single source of information that will be extremely valuable to all professionals working in areas impacted by this toxic substance
This text presents scientific inquiry into the causes of environmental and occupational disease, and the means of reducing the toll of illness and death from environmental agents. The preventive strategies discussed include identifying agents causing disease, determining exposure to them, setting priorities for change based on risk assessment, educating citizens and workers, and regulatory approaches.
Author: Gunnar F. Nordberg
Publisher: Academic Press
Release Date: 2014-08-07
Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium