Bioprocess Engineering

Author: Michael L. Shuler
Publisher: Prentice Hall
ISBN: 9780132901413
Release Date: 2017-03-29
Genre: Technology & Engineering

The Leading Introduction to Biochemical and Bioprocess Engineering, Updated with Key Advances in Productivity, Innovation, and Safety Bioprocess Engineering, Third Edition, is an extensive update of the world’s leading introductory textbook on biochemical and bioprocess engineering and reflects key advances in productivity, innovation, and safety. The authors review relevant fundamentals of biochemistry, microbiology, and molecular biology, including enzymes, cell functions and growth, major metabolic pathways, alteration of cellular information, and other key topics. They then introduce evolving biological tools for manipulating cell biology more effectively and to reduce costs of bioprocesses. This edition presents major advances in the production of biologicals; highly productive techniques for making heterologous proteins; new commercial applications for both animal and plant cell cultures; key improvements in recombinant DNA microbe engineering; techniques for more consistent authentic post-translational processing of proteins; and other advanced topics. It includes new, improved, or expanded coverage of The role of small RNAs as regulators Transcription, translation, regulation, and differences between prokaryotes and eukaryotes Cell-free processes, metabolic engineering, and protein engineering Biofuels and energy, including coordinated enzyme systems, mixed-inhibition and enzyme-activation kinetics, and two-phase enzymatic reactions Synthetic biology The growing role of genomics and epigenomics Population balances and the Gompetz equation for batch growth and product formation Microreactors for scale-up/scale-down, including rapid scale-up of vaccine production The development of single-use technology in bioprocesses Stem cell technology and utilization Use of microfabrication, nanobiotechnology, and 3D printing techniques Advances in animal and plant cell biotechnology The text makes extensive use of illustrations, examples, and problems, and contains references for further reading as well as a detailed appendix describing traditional bioprocesses. Register your product at informit.com/register for convenient access to downloads, updates, and corrections as they become available.

Elements of Chemical Reaction Engineering

Author: H. Scott Fogler
Publisher: Prentice Hall
ISBN: 0133887510
Release Date: 2016-01-08
Genre: Chemical reactors

The Definitive, Fully Updated Guide to Solving Real-World Chemical Reaction Engineering Problems For decades, H. Scott Fogler's Elements of Chemical Reaction Engineering has been the world's dominant text for courses in chemical reaction engineering. Now, Fogler has created a new, completely updated fifth edition of his internationally respected book. The result is a refined book that contains new examples and problems, as well as an updated companion Web site. More than ever, Fogler has successfully integrated text, visuals, and computer simulations to help both undergraduate and graduate students master all of the field's fundamentals. As always, he links theory to practice through many relevant examples, ranging from standard isothermal and non-isothermal reactor design to applications, such as solar energy, blood clotting, and drug delivery, and computer chip manufacturing. To promote the transfer of key skills to real-life settings, Fogler presents the following three styles of problems: 1. Straightforward problems that reinforce the principles of chemical reaction engineering 2. Living Example Problems (LEPs) that allow students to rapidly explore the issues and look for optimal solutions 3. Open-ended problems that encourage students to practice creative problem-solving skills ABOUT THE WEB SITE The companion Web site offers extensive enrichment opportunities and additional content, including Complete PowerPoint slides for lecture notes for chemical reaction engineering classes. Links to additional software, including POLYMATH(tm), Matlab(tm), Wolfram Mathematica(tm), AspenTech(tm), and COMSOL(tm). Interactive learning resources linked to each chapter, including Learning Objectives, Summary Notes, Web Modules, Interactive Computer Games, Solved Problems, FAQs, additional homework problems, and links to Learncheme. Living Example Problems that provide more than eighty interactive simulations, allowing students to explore the examples and ask "what-if" questions. The LEPs are unique to this book. Professional Reference Shelf, which includes advanced content on reactors, weighted least squares, experimental planning, laboratory reactors, pharmacokinetics, wire gauze reactors, trickle bed reactors, fluidized bed reactors, CVD boat reactors, detailed explanations of key derivations, and more. Problem-solving strategies and insights on creative and critical thinking.

Fundamentals of Chemical Engineering Thermodynamics

Author: Themis Matsoukas
Publisher: Pearson Education
ISBN: 9780132693066
Release Date: 2013
Genre: Science

The Clear, Well-Organized Introduction to Thermodynamics Theory and Calculations for All Chemical Engineering Undergraduate Students This text is designed to make thermodynamics far easier for undergraduate chemical engineering students to learn, and to help them perform thermodynamic calculations with confidence. Drawing on his award-winning courses at Penn State, Dr. Themis Matsoukas focuses on “why” as well as “how.” He offers extensive imagery to help students conceptualize the equations, illuminating thermodynamics with more than 100 figures, as well as 190 examples from within and beyond chemical engineering. Part I clearly introduces the laws of thermodynamics with applications to pure fluids. Part II extends thermodynamics to mixtures, emphasizing phase and chemical equilibrium. Throughout, Matsoukas focuses on topics that link tightly to other key areas of undergraduate chemical engineering, including separations, reactions, and capstone design. More than 300 end-of-chapter problems range from basic calculations to realistic environmental applications; these can be solved with any leading mathematical software. Coverage includes • Pure fluids, PVT behavior, and basic calculations of enthalpy and entropy • Fundamental relationships and the calculation of properties from equations of state • Thermodynamic analysis of chemical processes • Phase diagrams of binary and simple ternary systems • Thermodynamics of mixtures using equations of state • Ideal and nonideal solutions • Partial miscibility, solubility of gases and solids, osmotic processes • Reaction equilibrium with applications to single and multiphase reactions

Chemical Process Safety

Author: Daniel A. Crowl
Publisher: Pearson Education
ISBN: 9780132440554
Release Date: 2001-10-16
Genre: Technology & Engineering

Combines academic theory with practical industry experience Updated to include the latest regulations and references Covers hazard identification, risk assessment, and inherent safety Case studies and problem sets enhance learning Long-awaited revision of the industry best seller. This fully revised second edition of Chemical Process Safety: Fundamentals with Applications combines rigorous academic methods with real-life industrial experience to create a unique resource for students and professionals alike. The primary focus on technical fundamentals of chemical process safety provides a solid groundwork for understanding, with full coverage of both prevention and mitigation measures. Subjects include: Toxicology and industrial hygiene Vapor and liquid releases and dispersion modeling Flammability characterization Relief and explosion venting In addition to an overview of government regulations, the book introduces the resources of the AICHE Center for Chemical Process Safety library. Guidelines are offered for hazard identification and risk assessment. The book concludes with case histories drawn directly from the authors' experience in the field. A perfect reference for industry professionals, Chemical Process Safety: Fundamentals with Applications, Second Edition is also ideal for teaching at the graduate and senior undergraduate levels. Each chapter includes 30 problems, and a solutions manual is now available for instructors.

Essentials of Chemical Reaction Engineering

Author: H. Scott Fogler
Publisher: Pearson Education
ISBN: 9780137146123
Release Date: 2011
Genre: Technology & Engineering

Learn Chemical Reaction Engineering through Reasoning, Not Memorization Essentials of Chemical Reaction Engineering is the complete, modern introduction to chemical reaction engineering for today's undergraduate students. Starting from the strengths of his classic Elements of Chemical Reaction Engineering, Fourth Edition, in this volume H. Scott Fogler added new material and distilled the essentials for undergraduate students. Fogler's unique way of presenting the material helps students gain a deep, intuitive understanding of the field's essentials through reasoning, using a CRE algorithm, not memorization. He especially focuses on important new energy and safety issues, ranging from solar and biomass applications to the avoidance of runaway reactions. Thoroughly classroom tested, this text reflects feedback from hundreds of students at the University of Michigan and other leading universities. It also provides new resources to help students discover how reactors behave in diverse situations-including many realistic, interactive simulations on DVD-ROM. New Coverage Includes Greater emphasis on safety: following the recommendations of the Chemical Safety Board (CSB), discussion of crucial safety topics, including ammonium nitrate CSTR explosions, case studies of the nitroaniline explosion, and the T2 Laboratories batch reactor runaway Solar energy conversions: chemical, thermal, and catalytic water spilling Algae production for biomass Steady-state nonisothermal reactor design: flow reactors with heat exchange Unsteady-state nonisothermal reactor design with case studies of reactor explosions About the DVD-ROM The DVD contains six additional, graduate-level chapters covering catalyst decay, external diffusion effects on heterogeneous reactions, diffusion and reaction, distribution of residence times for reactors, models for non-ideal reactors, and radial and axial temperature variations in tubular reactions. Extensive additional DVD resources include Summary notes, Web modules, additional examples, derivations, audio commentary, and self-tests Interactive computer games that review and apply important chapter concepts Innovative "Living Example Problems" with Polymath code that can be loaded directly from the DVD so students can play with the solution to get an innate feeling of how reactors operate A 15-day trial of Polymath(tm) is included, along with a link to the Fogler Polymath site A complete, new AspenTech tutorial, and four complete example problems Visual Encyclopedia of Equipment, Reactor Lab, and other intuitive tools More than 500 PowerPoint slides of lecture notes Additional updates, applications, and information are available at www.umich.edu/~essen and www.essentialsofcre.com.

Bioseparations Science and Engineering

Author: Roger G. Harrison
Publisher: Oxford University Press
ISBN: 9780190213732
Release Date: 2015-01-27
Genre: Technology & Engineering

Designed for undergraduates, graduate students, and industry practitioners, Bioseparations Science and Engineering fills a critical need in the field of bioseparations. Current, comprehensive, and concise, it covers bioseparations unit operations in unprecedented depth. In each of the chapters, the authors use a consistent method of explaining unit operations, starting with a qualitative description noting the significance and general application of the unit operation. They then illustrate the scientific application of the operation, develop the required mathematical theory, and finally, describe the applications of the theory in engineering practice, with an emphasis on design and scaleup. Unique to this text is a chapter dedicated to bioseparations process design and economics, in which a process simular, SuperPro Designer? is used to analyze and evaluate the production of three important biological products. New to this second edition are updated discussions of moment analysis, computer simulation, membrane chromatography, and evaporation, among others, as well as revised problem sets. Unique features include basic information about bioproducts and engineering analysis and a chapter with bioseparations laboratory exercises. Bioseparations Science and Engineering is ideal for students and professionals working in or studying bioseparations, and is the premier text in the field.

Disposable Bioreactors

Author: Regine Eibl
Publisher: Springer Science & Business Media
ISBN: 9783642018718
Release Date: 2009-11-27
Genre: Science

Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.

Chemical Process Equipment

Author: James R. Couper
Publisher: Elsevier
ISBN: 9780123972361
Release Date: 2012-12-06
Genre: Technology & Engineering

Chemical Process Equipment is a results-oriented reference for engineers who specify, design, maintain or run chemical and process plants. This book delivers information on the selection, sizing and operation of process equipment in a format that enables quick and accurate decision making on standard process and equipment choices, saving time, improving productivity, and building understanding. Coverage emphasizes common real-world equipment design rather than experimental or esoteric and focuses on maximizing performance. Legacy reference for chemical and related engineers who work with vendors to design, specify and make final equipment selection decisions Copious examples of successful applications, with supporting schematics and data to illustrate the functioning and performance of equipment Provides equipment rating forms and manufacturers’ data, worked examples, valuable shortcut methods, and rules of thumb to demonstrate and support the design process Heavily illustrated with line drawings and schematics to aid understanding, as well as graphs and tables to illustrate performance data

Analysis Synthesis and Design of Chemical Processes

Author: Richard Turton
Publisher: Prentice Hall
ISBN: 9780132618120
Release Date: 2012
Genre: Technology & Engineering

"Process design is the focal point of chemical engineering practice: the creative activity through which engineers continuously improve facility operations to create products that enhance life. Effective chemical engineering design requires students to integrate a broad spectrum of knowledge and intellectual skills, so they can analyze both the big picture and minute details - and know when to focus on each. Through three previous editions, this book has established itself as the leading resource for students seeking to apply what they've learned in real-world, open-ended process problems. The authors help students hone and synthesize their design skills through expert coverage of preliminary equipment sizing, flowsheet optimization, economic evaluation, operation and control, simulation, and other key topics. This new Fourth Edition is extensively updated to reflect new technologies, simulation techniques, and process control strategies, and to include new pedagogical features including concise summaries and end-of-chapter lists of skills and knowledge."--pub. desc.

Metabolic Engineering

Author: Jens Nielsen
Publisher: Springer
ISBN: 9783540453000
Release Date: 2003-07-03
Genre: Science

Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.

Process Systems Analysis and Control

Author: Donald R. Coughanowr
Publisher: McGraw-Hill Science, Engineering & Mathematics
ISBN: 0070132127
Release Date: 1991-01-01
Genre: Technology & Engineering

A thorough revision of the best-selling text on Process Dynamics and Control, the new edition features inclusion of the use of the digital computer in problem solving. The volume also contains seventeen fundamentals chapters. New end-of-chapter problems and examples have been added. PC-based software by Tutsim Products is packaged with the solutions manual.

Principles and Modern Applications of Mass Transfer Operations

Author: Jaime Benitez
Publisher: John Wiley & Sons
ISBN: 9781119276944
Release Date: 2016-12-16
Genre: Technology & Engineering

A staple in any chemical engineering curriculum New edition has a stronger emphasis on membrane separations, chromatography and other adsorptive processes, ion exchange Discusses many developing topics in more depth in mass transfer operations, especially in the biological engineering area Covers in more detail phase equilibrium since distillation calculations are completely dependent on this principle Integrates computational software and problems using Mathcad Features 25-30 problems per chapter

Bioprocess Engineering

Author: Shijie Liu
Publisher: Elsevier
ISBN: 9780444637932
Release Date: 2016-08-29
Genre: Technology & Engineering

Bioprocess Engineering: Kinetics, Sustainability, and Reactor Design, Second Edition, provides a comprehensive resource on bioprocess kinetics, bioprocess systems, sustainability, and reaction engineering. Author Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics, batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering, also introducing key principles that enable bioprocess engineers to engage in analysis, optimization, and design with consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme in this book, with more advanced techniques and applications being covered in depth. This updated edition reflects advances that are transforming the field, ranging from genetic sequencing, to new techniques for producing proteins from recombinant DNA, and from green chemistry, to process stability and sustainability. The book introduces techniques with broad applications, including the conversion of renewable biomass, the production of chemicals, materials, pharmaceuticals, biologics, and commodities, medical applications, such as tissue engineering and gene therapy, and solving critical environmental problems. Includes the mechanistic description of biotransformations and chemical transformations Provides quantitative descriptions of bioprocesses Contains extensive illustrative drawings, which make the understanding of the subject easy Includes bioprocess kinetics and reactor analysis Contains examples of the various process parameters, their significance, and their specific practical use Incorporates sustainability concepts into the various bioprocesses

Small Bioreactors for Management of Biodegradable Waste

Author: Pranas Baltrėnas
Publisher: Springer
ISBN: 9783319782119
Release Date: 2018-06-01
Genre: Science

This volume discusses how small bioreactors can produce useful biogas and compost from biodegradable waste. The authors identify which biodegradable wastes are optimal for small bioreactors, and how these choices can be used to increase bioreactor productivity. Additionally, readers will learn about how the amount and composition of biogas is estimated, the concentration of biodegradable waste that needs to be supplied to a bioreactor, the development of small bioreactors including the ratio of cost to the obtained benefits, and the nature of biodegradable wastes generated by both small farms and large food industry enterprises. The beginning chapters explain what biodegradable waste is, show how to predict how much waste an enterprise will produce, and elaborate the characteristics of the biogas which is generated from biodegradable waste in small bioreactors. Then the book discusses the types of small bioreactors and how to select the optimal bioreactor for a given case. Bioreactor performance is analyzed on both an economical and production efficiency basis, with experimental results provided on the quantity and quality of the biogas produced. The final chapters address how small bioreactors can be incorporated into small biogas plants, and the potential use of small bioreactors in countries with high demand for alternative energy using the case of Lithuania. The audience for this work includes specialists in biodegradable waste management and utilization enterprises, designers, and academics, researchers and students engaged in environmental engineering.