Cold Spring Harbor

Author: Richard Yates
Publisher: Random House
ISBN: 9781407015163
Release Date: 2010-12-23
Genre: Fiction

Evan Shepard is a young man with a chequered past when he first meets the Drakes, after his car breaks down outside their house. Behind him, he has a troubled adolescence, a failed marriage and a little daughter, but his meeting with the quiet and beautiful Rachel heralds a new start. However, after their swift marriage, things don't work out quite as planned and the stresses of living with Rachel's family, in their shared house in Cold Spring Harbor, begin to take their toll on the new couple.

Enjoy Your Cells

Author: Frances R. Balkwill
Publisher: CSHL Press
ISBN: 0879695846
Release Date: 2001-10-01
Genre: Juvenile Nonfiction

Describes different kinds of cells and the work that they do inside living things.

Life Illuminated

Author: Jan Anthony Witkowski
Publisher: CSHL Press
ISBN: 9780879698041
Release Date: 2008
Genre: Science

From the late 1960s through the early 1990s, Cold Spring Harbor Laboratory was directed by James Watson. This volume highlights 34 of the 1500 research papers published during that golden period, which are reproduced (on a CD) with commentaries from the scientists who did the work. The papers were selected because they opened a new avenue of scientific investigation, or marked an important milestone in a field's development, or brought a field to intellectual closure.

Methods in Yeast Genetics

Author: David C. Amberg
Publisher: CSHL Press
ISBN: 9780879697280
Release Date: 2005
Genre: Science

"Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.

Essentials of Glycobiology

Author: Ajit Varki
Publisher: CSHL Press
ISBN: 0879696818
Release Date: 1999-01-01
Genre: Science

Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

The P53 Family

Author: Arnold Jay Levine
ISBN: 0879698306
Release Date: 2010
Genre: Medical

This volume offers a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, their evolution, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis.

DNA Replication and Human Disease

Author: Melvin L. DePamphilis
Publisher: CSHL Press
ISBN: 9780879697662
Release Date: 2006
Genre: Medical

This is a second edition of DNA Replication in Eukaryotic Cells, published in 1996. This up-to-date monograph provides a broad account of DNA replication and related functions such as DNA repair and protein phosphorylation, as well as a review of recent advances in understanding the complex gene and protein interactions that underpin this essential cellular function. The new edition not only summarizes the many advances in our understanding of DNA replication in eukaryotic cells that have occurred during the past decade, but also will stimulate thinking about the relationships between DNA replication, human disease, and targeted therapeutics.


Author: Andrew J. Link
ISBN: 0879697873
Release Date: 2009
Genre: Medical

Based on a popular course at Cold Spring Harbor Laboratory, this new manual assembles cutting–edge protocols, helpful hints, and lecture notes to teach researchers from a variety of disciplines the essential methods of proteomics. It provides well–illustrated descriptions of experimental procedures, detailed protocols involving state–of–the–art instrumentation, and lists of recommended Web sites and reading material. It can be used as the basis for a course or as a detailed bench manual, and is indispensable for those performing proteomic experiments.

Imaging in Neuroscience and Development

Author: Rafael Yuste
Publisher: CSHL Press
ISBN: 9780879696924
Release Date: 2005-01-01
Genre: Medical

As imaging studies have continued to expand in scope and sophistication, this new edition of the highly successful and well–received Imaging Neurons: A Laboratory Manualhas expanded to include development, with over twenty new chapters on such topics as MRI microscopy, imaging early developmental events, and labeling single neurons. Chapters on FRET, FCS/ICS, FRAP, hyperresolution microscopy, single molecule imaging, imaging with quantum dots, and imaging gene expression are included. With over forty full chapters, the manual also includes over forty sections of protocols for imaging techniques.

Invertebrate Neurobiology

Author: Geoffrey North
Publisher: CSHL Press
ISBN: 9780879698195
Release Date: 2007
Genre: Medical

This monograph captures the current excitement in invertebrate neurobiology, from the manipulation of activity in specified neurons to the investigation of behavior. The monograph emphasizes the evolutionary aspects of neurobiology and work on non-model species. The chapters, from internationally respected contributors, incorporate trenchant findings but also identify important outstanding questions. The volume will inspire graduate students and post-docs, and provide a good starting point for any scientist who wants to learn about this resurgent field.


Author: C. David Allis
Publisher: CSHL Press
ISBN: 9780879697242
Release Date: 2007-01
Genre: Medical

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

C Elegans II

Author: Donald L. Riddle
Publisher: Firefly Books
ISBN: 0879695323
Release Date: 1997
Genre: Medical

Studies of the cells and genes of the nematode C. elegans have become a cornerstone of current biology. A classic 1988 Cold Spring Harbor monograph, The Nematode Caenorhabditis elegans, described the basic genetics, anatomy and development of the organism. Now, in that authoritative tradition, comes C. elegans II -- not a second edition but a book that breaks new ground and defines the current status of the field, providing a detailed molecular explanation of how development is regulated and the nervous system specifies varied aspects of behavior. This volume is a must for any investigator doing worm studies but it has been written and rigorously edited to illuminate for a wider community of investigators in cell and molecular biology who should know how new knowledge of C. elegans relates to their own specialty.

Clocks and Rhythms

Author: Cold Spring Harbor Laboratory
Publisher: CSHL Press
ISBN: 9780879698232
Release Date: 2007
Genre: Medical

Based on presentations by world–renowned investigators at the 72nd annual Cold Spring Harbor Symposium on Quantitative Biology, this volume reviews the latest advances in biological clocks and rhythms. Topics include genetic and cellular studies aimed at characterizing circadian mechanisms; systems approaches to understanding physiological, endocrine, and neural networks; and models used for studying mental and physical cycles. A variety of normal and abnormal chronobiological patterns are discussed, including sleep, aging, migration, hibernation, seasonality, depression, and arrhythmias.