Author: Alison McCurdy
Publisher: Oxford University Press, USA
Release Date: 2016-07-01
Concepts in Bioinformatics and Genomics takes a conceptual approach to its subject, balancing biology, mathematics, and programming, while highlighting relevant real-world applications. Topics are developed from the fundamentals up like in an introductory textbook. This is a comprehensive bookfor students enrolled in their first course in bioinformatics. A compelling case study gene, the TP53 gene, a human tumor suppressor with strong clinical applications, runs throughout, engaging students with a continuously relevant example.The textbook thoroughly describes basic principles of probability as they lead up to the concept of expectation value (E-value) and its use in sequence alignment programs. Concepts in Bioinformatics and Genomics also describes, from a mathematical perspective, the development of the Hidden MarkovModel and how it can be used to align sequences in multiple sequence alignment programs. Finally, it introduces students to programming exercises directly related to bioinformatics problems. These thought-provoking exercises stretch the students' imaginations and learning, giving them a deeperunderstanding of software programs, molecular biology, basic probability, and program-coding methodology underpinning the discipline. They will have the tools necessary to compute biological data.
Author: Rainer Merkl
Publisher: John Wiley & Sons
Release Date: 2015-04-13
Jetzt in dritter Auflage komplett ?berarbeitet und im Bereich des maschinellen Lernens stark erweitert. Ein perfekte Einf?hrung f?r alle Studenten der Lebenswissenschaften oder Informatik, die einen Einblick in die g?ngigen Methoden der Bioinformatik ben?tigen.
Author: Philip T. Cagle
Publisher: Springer Science & Business Media
Release Date: 2009-06-10
Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.
Author: Andreas D. Baxevanis
Publisher: John Wiley & Sons
Release Date: 2004-03-24
"In this book, Andy Baxevanis and Francis Ouellette . . . have undertaken the difficult task of organizing the knowledge in this field in a logical progression and presenting it in a digestible form. And they have done an excellent job. This fine text will make a major impact on biological research and, in turn, on progress in biomedicine. We are all in their debt." —Eric Lander from the Foreword Reviews from the First Edition "...provides a broad overview of the basic tools for sequence analysis ... For biologists approaching this subject for the first time, it will be a very useful handbook to keep on the shelf after the first reading, close to the computer." —Nature Structural Biology "...should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data." —Science "...a wonderful primer designed to navigate the novice through the intricacies of in scripto analysis ... The accomplished gene searcher will also find this book a useful addition to their library ... an excellent reference to the principles of bioinformatics." —Trends in Biochemical Sciences This new edition of the highly successful Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins provides a sound foundation of basic concepts, with practical discussions and comparisons of both computational tools and databases relevant to biological research. Equipping biologists with the modern tools necessary to solve practical problems in sequence data analysis, the Second Edition covers the broad spectrum of topics in bioinformatics, ranging from Internet concepts to predictive algorithms used on sequence, structure, and expression data. With chapters written by experts in the field, this up-to-date reference thoroughly covers vital concepts and is appropriate for both the novice and the experienced practitioner. Written in clear, simple language, the book is accessible to users without an advanced mathematical or computer science background. This new edition includes: All new end-of-chapter Web resources, bibliographies, and problem sets Accompanying Web site containing the answers to the problems, as well as links to relevant Web resources New coverage of comparative genomics, large-scale genome analysis, sequence assembly, and expressed sequence tags A glossary of commonly used terms in bioinformatics and genomics Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, Second Edition is essential reading for researchers, instructors, and students of all levels in molecular biology and bioinformatics, as well as for investigators involved in genomics, positional cloning, clinical research, and computational biology.
Author: Venkatarajan Mathura
Publisher: Springer Science & Business Media
Release Date: 2008-10-11
Bioinformatics is an evolving field that is gaining popularity due to genomics, proteomics and other high-throughput biological methods. The function of bioinformatic scientists includes biological data storage, retrieval and in silico analysis of the results from large-scale experiments. This requires a grasp of knowledge mining algorithms, a thorough understanding of biological knowledge base, and the logical relationship of entities that describe a process or the system. Bioinformatics researchers are required to be trained in multidisciplinary fields of biology, mathematics and computer science. Currently the requirements are satisfied by ad hoc researchers who have specific skills in biology or mathematics/computer science. But the learning curve is steep and the time required to communicate using domain specific terms is becoming a major bottle neck in scientific productivity. This workbook provides hands-on experience which has been lacking for qualified bioinformatics researchers.
Author: Allen G. Taylor
Publisher: John Wiley & Sons
Release Date: 2017-04-24
Daten und Datenbanken sind quasi ï¿1⁄2berall. Mit der Standardabfragesprache SQL kï¿1⁄2nnen Daten in relationalen Datenbanken einfach, strukturiert und zielsicher abgefragt werden. Erfahren Sie in diesem Buch, welches kein Vorwissen voraussetzt, wie man Datenbanken erstellt, wie man Daten ordnet und abfragt und wie man SQL-Anweisungen in Programme und Websites einbindet. Nutzen Sie dieses Buch auch als Nachschlagewerk. Ganz wichtig: Sie lernen auch, wie Sie Ihre Datenbanken und Daten schï¿1⁄2tzen und wie Sie typische Fehler vermeiden.
This is an innovative textbook for undergraduates as well as postgraduates offering basic knowledge of biology. Its aim is to provide state-of-the-art information about this developing science that has the potential to replace existing biological approaches to study genes and proteins. The chapters are explained in a concise yet detailed manner, including ample cross-references, references to literature and databases, tables and illustrations. The book's sound approach to this intricately complex field makes it an exceptional resource for further exploration into biochemistry, molecular biology, genomics and drug designing fields. Abundant learning features make this book the ideal teaching and learning tool. KEY FEATURES • Illustrations to bolster understanding of complex biochemical relations • Tables for quick access to precise data • Extensive end-of-chapter exercises and references • The most basic details furnished for those who are new to biology • User-friendly, Internet-based bioinformatics tools that allow researchers to extract information from databases and analyze it • Analysis of one software tool discussed in each chapter step-by-step from entering the input till interpretation of the results This is an in-depth textbook written for the biologist who wants a thorough understanding of the popular bioinformatics programs and molecular databases currently in use. It provides a broad, application-oriented overview of this technology.
Author: Information Resources Management Association
Publisher: IGI Global
Release Date: 2013-03-31
"Bioinformatics: Concepts, Methodologies, Tools, and Applications highlights the area of bioinformatics and its impact over the medical community with its innovations that change how we recognize and care for illnesses"--Provided by publisher.
Author: Ivan Y. Torshin
Publisher: Nova Publishers
Release Date: 2006
Biomedicine is one of the most important fields for the prospective applications of the information from human genome studies. However, there are many 'white spots' in the present-day understanding of the biomedical implications of this information. Given that at least half of the proteins in the established sequence of the human genome have no annotation whatsoever and that the sequence similarity searches are not likely to produce any, definite research strategies to analyse the functions of these unknown proteins as well as other enigmatic aspects of the human genome are being elaborated. The elaboration of the logistics of these research strategies, of the relevant computational methodologies as well as the general management of the informational complexity of the biological systems belong to the main tasks for the post-genomic bioinformatics. This volume concentrates on the role of the biophysical studies and biophysical concepts that can assist the endeavour.
1. Introduction to Bioinformatics 2. Introduction to Computers 3. Introduction to Internet 4. Search Engines: Tools for Web Search 5. Programming Languages 6. Genomics and Proteomics 7. Biological Databases 8. Sequence Analysis 9. Phylogenetic Analysis 10. Microarray Technology: A Boon to Biological Sciences 11. Bioinformatic..s in Drug Discovery: A Brief Overview 12. Genome Sequencing Projects 13. BTIS Network In India Index
The advances in genomic technologies, such as microarrays and high throughput sequencing, have expanded the realm of possibilities for capturing data and analyzing it using automated computer driven bioinformatics tools. With the completion of the sequencing of genomes of human and several model organisms, a quest for scientific discoveries being fueled by integrative and multidimensional techniques in mathematics and computational sciences. In this volume, leading researchers and experts have provided an overview of significant concepts from biological, mathematical, and computational perspectives. It provides a high level view of fungal genomic data integration and annotation, classification of proteins and identification of vaccine targets, identification of secretome or secreted proteins in fungal genomes, as well as tools for analyzing microarray expression profiles. Provides a survey of theoretical underpinnings on the technological tools and applications Discusses the tools utilized for the annotation of fungal genomes and addresses issues related to automated annotation generation in a high throughput biotechnology environment Describes the applications of the concepts and methodologies presented throughout the book
Author: Rex A. Dwyer
Publisher: Cambridge University Press
Release Date: 2003
This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Author: Management Association, Information Resources
Publisher: IGI Global
Release Date: 2014-04-30
Genre: Technology & Engineering
Following the migration of workflows, data, and communication to the Cloud and other Internet-based frameworks, interaction over the Web has become ever more commonplace. As with any social situation, there are rules and consequences to actions within a virtual environment. Cyber Behavior: Concepts, Methodologies, Tools, and Applications explores the role of cyberspace in modern communication and interaction, including considerations of ethics, crime, security, and education. With chapters on a variety of topics and concerns inherent to a contemporary networked society, this multi-volume work will be of particular interest to students and academicians, as well as software developers, computer scientists, and specialists in the field of Information Technologies.
Bioinformatics aids the discipline of biology by developing tools and techniques to interpret and analyze all types of biological data through numerical and computational modeling. The focus of this book lies in the concepts of genome annotation, structural bioinformatics, comparative genomics, etc. It aims to bring forth the latest researches from across the globe to keep the readers updated with the progress of this field. This text is an apt reference material for students, academicians as well as professionals.