Author: Singer Michael Alan
Publisher: World Scientific
Release Date: 2015-01-23
Human Ageing: A Unique Experience explores the biology of human ageing focusing on the individual. The book begins with the premature ageing disorder Hutchinson-Gilford Progeria syndrome and spins a web of interconnected biological domains involving lamins, telomeres, alternative splicing, genetics, epigenetics, and molecular clocks. The profound influence of culture is explored since cultural inheritance and genetic inheritance are the two intertwined processes driving human evolution. An empirical framework is developed to describe human ageing at the individual level and the implications of this framework on the whole concept of diseases are discussed.
Release Date: 1968
Genre: Electric power
Contains all the formal opinions and accompanying orders of the Federal Power Commission ... In addition to the formal opinions, there have been included intermediate decisions which have become final and selected orders of the Commission issued during such period.
Providing an interface between dry-bench bioinformaticians and wet-lab biologists, DNA Methylation Microarrays: Experimental Design and Statistical Analysis presents the statistical methods and tools to analyze high-throughput epigenomic data, in particular, DNA methylation microarray data. Since these microarrays share the same underlying principles as gene expression microarrays, many of the analyses in the text also apply to microarray-based gene expression and histone modification (ChIP-on-chip) studies. After introducing basic statistics, the book describes wet-bench technologies that produce the data for analysis and explains how to preprocess the data to remove systematic artifacts resulting from measurement imperfections. It then explores differential methylation and genomic tiling arrays. Focusing on exploratory data analysis, the next several chapters show how cluster and network analyses can link the functions and roles of unannotated DNA elements with known ones. The book concludes by surveying the open source software (R and Bioconductor), public databases, and other online resources available for microarray research. Requiring only limited knowledge of statistics and programming, this book helps readers gain a solid understanding of the methodological foundations of DNA microarray analysis.
Author: Thomas Roy Crompton
Publisher: Oxford University Press, USA
Release Date: 1993
One of the problems in the analysis of natural and potable waters is that the equipment used is often insufficiently sensitive to detect the low concentrations of organic and inorganic substances present in the samples. The problem can, however, be overcome to some extent by preconcentrating the sample before analysis. This two-volume set provides a comprehensive review of the techniques available for preconcentration and explains how each can be applied to cations, anions, organic substances, and organometallic compounds. Volume 1 describes methods involving complex formation, while Volume 2 covers direct preconcentration techniques. Both books contain useful practical advice which will be of value to all analytical chemists and environmental scientists concerned with water analysis.