Handbook of Pharmacogenomics and Stratified Medicine

Author:
Publisher: Academic Press
ISBN: 9780123868831
Release Date: 2014-04-28
Genre: Science

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Der Experimentator Molekularbiologie Genomics

Author: Cornel Mülhardt
Publisher: Springer-Verlag
ISBN: 9783642346361
Release Date: 2013-08-27
Genre: Science

Dieses Buch enthält das Grundlagenwissen sowie Tipps und Tricks für den Umgang mit Nucleinsäuren. Der Autor kennt Lust und Frust der täglichen Laborroutine ganz genau. Präparieren, Fällen, Konzentrieren und Reinigen von Nucleinsäuren Restriktionsenzyme, Gele, Blotten Polymerase-Kettenreaktion RNA-Isolierung, -Transkription Klonierung von DNA-Fragmenten Markierung von Sonden, Hybridisierung, Screening, Sequenzierung Mutagenese, In-vitro-Translation, transgene Mäuse, Transgenexpression, Gentherapie, Genomik Dieses Buch richtet sich an alle Experimentatoren, die molekularbiologische Versuche durchführen wollen und gern nachvollziehen möchten, was sich in ihrem Reaktionsgefäß abspielt. Das ganze Spektrum der üblichen molekularbiologischen Methoden wird vorgestellt, kommentiert und Alternativen aufgezeigt. Der lockere Ton wendet sich gleichermaßen an Studenten wie an BTAs und Laboranten, aber auch der alte Hase wird hier und dort noch etwas Neues entdecken. Die 7. Auflage wurde überarbeitet und aktualisiert.

Routledge Handbook of Medical Law and Ethics

Author: Yann Joly
Publisher: Routledge
ISBN: 9781134448654
Release Date: 2014-09-19
Genre: Law

This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.

P diatrische Dermatologie

Author: Bernard A. Cohen
Publisher: Elsevier,Urban&FischerVerlag
ISBN: 9783437592645
Release Date: 2013-05-06
Genre: Medical

Mit diesem Lehrbuch und Atlas erhalten Sie sowohl ein Referenzwerk für den Einsatz in der Praxis als auch für die Ausbildung im Bereich der Pädiatrischen Dermatologie. Neu in der 2. Auflage: Über 800 hervorragende Abbildungen Orientiert an klinischen Fragestellungen Hilfreiche Texte zu Diagnose, Klinik und Therapie Algorithmen und Übersichtstabellen zur einfachen Differenzialdiagnose Sinnvolle Gliederung zum schnellen Nachschlagen

World Scientific Handbook Of Global Health Economics And Public Policy A 3 volume Set

Author: Scheffler Richard M
Publisher: World Scientific
ISBN: 9789814612333
Release Date: 2016-01-28
Genre: Health & Fitness

This Handbook covers major topics in global health economics and public policy and provides a timely, systematic review of the field. Edited by Richard M Scheffler, Distinguished Professor of Health Economics and Public Policy and Director of the Global Center for Health Economics and Policy Research at the University of California, Berkeley, the Handbook features academics and practitioners from more than a dozen countries. Contributors are from the London School of Economics and Political Science, Pompeu Fabra University in Barcelona, University of York, University of Oslo, London School of Hygiene and Tropical Medicine, University of California - Berkeley, Stanford University, Johns Hopkins University, University of Toronto, University of Oxford, Harvard Medical School, OECD, the World Health Organization and the World Bank, many of whom have also acted as economic and policy advisors to government and non-governmental organizations across the world. Experts in these areas who provide critical analyses and relevant data for further exploration and research include: Thomas E Getzen, Executive Director of the International Health Economics Association (iHEA); Douglas E Hough, Associate Scientist and Associate Director of the Master in Healthcare Management programme at the Bloomberg School of Public Health of John Hopkins University; Guillem López-Casasnovas, former President of iHEA and member of the Advisory Council of the Spanish Health and Social Welfare Ministry and of the Advisory Council of the Catalan Health Ministry since 1984; Alistair McGuire, Professor of Health Economics at the London School of Economics and Political and advisor to a number of governments and governmental bodies across Europe; Tor Iversen, Research Director at the Health Economics Research Programme at the University of Oslo and former member of the iHEA Arrow Award Committee 2007-2011; William H Dow, Professor and Associate Dean for Research at University of California ,Berkeley and former Senior Economist for the Council of Economic Advisors (White House); Audrey Laporte, the Director of the Canadian Centre for Health Economics; Alexander S Preker, President and CEO of Health Investment & Financing Corporation; Ayda Yurekli, who initiated and developed the World Health Organization TaXSiM simulation model that has been used by many Ministries of Finance around the world for the development of tax policies; Marko Vujicic, Managing Vice President of the Health Policy Resources Center at the American Dental Association; Mark Sculpher, Director of the Programme on Economic Evaluation and Health Technology Assessment at the University of York and former President of the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) (2011-2012); and Peter Berman, who has had almost 40 years of experience in global health and was formerly a Lead Health Economist at the World Bank. The Handbook spans across three volumes. The chapters deal with key global issues in health economics, are evidence-based, and offer innovative policy alternatives and solutions. The Handbook's approach toward global health economics and public policy will make it a useful resource for health economists, policymakers, private sector companies, NGOs, government decision-makers and those who manage healthcare systems.

Handbook of Decision Analysis

Author: Gregory S. Parnell, PhD
Publisher: John Wiley & Sons
ISBN: 9781118515846
Release Date: 2013-01-24
Genre: Business & Economics

A ONE-OF-A-KIND GUIDE TO THE BEST PRACTICES IN DECISION ANALYSIS Decision analysis provides powerful tools for addressing complex decisions that involve uncertainty and multiple objectives, yet most training materials on the subject overlook the soft skills that are essential for success in the field. This unique resource fills this gap in the decision analysis literature and features both soft personal/interpersonal skills and the hard technical skills involving mathematics and modeling. Readers will learn how to identify and overcome the numerous challenges of decision making, choose the appropriate decision process, lead and manage teams, and create value for their organization. Performing modeling analysis, assessing risk, and implementing decisions are also addressed throughout. Additional features include: Key insights gleaned from decision analysis applications and behavioral decision analysis research Integrated coverage of the techniques of single- and multiple-objective decision analysis Multiple qualitative and quantitative techniques presented for each key decision analysis task Three substantive real-world case studies illustrating diverse strategies for dealing with the challenges of decision making Extensive references for mathematical proofs and advanced topics The Handbook of Decision Analysis is an essential reference for academics and practitioners in various fields including business, operations research, engineering, and science. The book also serves as a supplement for courses at the upper-undergraduate and graduate levels.

Knochenkrankheiten

Author: Claus-Peter Adler
Publisher: Springer-Verlag
ISBN: 9783662121603
Release Date: 2013-08-13
Genre: Medical

Dieses interdisziplinäre Nachschlagewerk bietet Ihnen das Fundament für Ihre exakte Diagnose und gezielte Therapie-Planung. o Sie erhalten einen praxisorientierten Überblick über alle modernen und etablierten Diagnostik-Verfahren. o Didaktisch übersichtlich stehen die jeweiligen radiologischen und pathologisch-anatomischen Strukturen dem Text gegenüber. o Kurzgefaßte Therapievorschläge ergänzen die diagnostischen Richtlinien. => Das aktuelle Nachschlagewerk für die multidisziplinäre Zusammenarbeit von Orthopäden, Radiologen, Rheumatologen und Pathologen. Schnell * präzise * praxisgerecht

Das Gen

Author: Siddhartha Mukherjee
Publisher:
ISBN: 3596032350
Release Date: 2019-02-20
Genre:


The price of innovation new estimates of drug development costs

Author: Christoph Fürleger
Publisher: GRIN Verlag
ISBN: 9783640791675
Release Date: 2011-01-04
Genre: Business & Economics

Studienarbeit aus dem Jahr 2010 im Fachbereich VWL - Finanzwissenschaft, Universität Bayreuth, Sprache: Deutsch, Abstract: Die vom Bundesministerim für Gesundheit ausgewiesenen Arzneimittelausgaben in der GKV verzeichneten in den letzten 10 Jahren einen nominalen Anstieg um 54,56 Prozent. Der Anteil an den Gesamtausgaben der GKV stieg in diesem Zeitraum von 14,52 auf 17,57 Prozent (vgl. BMG (2010), S. 1). Für das Jahr 2010 errechnete der Schätzerkreis der gesetzlichen Krankenversicherungen im Oktober 2009 eine Deckungslücke von 7,45 Milliarden Euro zwischen den Einnahmen und Ausgaben im Gesundheitsfond (vgl. BVA Schätzerkreis (2009). Zur Entlastung der Ausgabenseite in der GKV werden daher zahlreiche Maßnahmen u.a. im Bereich der Arzneimittelversorgung diskutiert. Im Fokus stehen dabei im Besonderen patentgeschützte Arzneimittel. Für diese Produkte konnte die Pharmaindustrie bisher die Preise, bis zum Erstattungshöchstbetrag, frei festsetzen. Neben der Kosten-Nutzen- Bewertung und weiteren Faktoren sollen nach der aktuellen Gesetzeslage bei der Festlegung des Erstattungshöchstbetrags auch die Entwicklungskosten von Medikamenten berücksichtigt werden (vgl. § 31 Abs. 2a SGB V).

Epidemiologie

Author: Leon Gordis
Publisher:
ISBN: 3932091639
Release Date: 2001
Genre: Epidemiology


Bergmedizin

Author: Andrew J. Pollard
Publisher:
ISBN: 3456844433
Release Date: 2007
Genre: