Mass Spectrometry

Author: Edmond de Hoffmann
Publisher: John Wiley & Sons
ISBN: 9781118681947
Release Date: 2013-04-03
Genre: Science

The latest edition of a highly successful textbook, MassSpectrometry, Third Edition provides students with a completeoverview of the principles, theories and key applications of modernmass spectrometry. All instrumental aspects of mass spectrometryare clearly and concisely described: sources, analysers anddetectors. Tandem mass spectrometry is introduced early on and thendeveloped in more detail in a later chapter. Emphasis is placedthroughout the text on optimal utilisation conditions. Variousfragmentation patterns are described together with analyticalinformation that derives from the mass spectra. This new edition has been thoroughly revised and updated and hasbeen redesigned to give the book a more contemporary look. As withprevious editions it contains numerous examples, references and aseries of exercises of increasing difficulty to encourage studentunderstanding. Updates include: Increased coverage of MALDI andESI, more detailed description of time of flight spectrometers, newmaterial on isotope ratio mass spectrometry, and an expanded rangeof applications. Mass Spectrometry, Third Edition is an invaluableresource for all undergraduate and postgraduate students using thistechnique in departments of chemistry, biochemistry, medicine,pharmacology, agriculture, material science and food science. It isalso of interest for researchers looking for an overview of thelatest techniques and developments.

Liquid Chromatography Mass Spectrometry Third Edition

Author: Wilfried M.A. Niessen
Publisher: CRC Press
ISBN: 1420014544
Release Date: 2006-08-09
Genre: Science

A constructive evaluation of the most significant developments in liquid chromatography–mass spectrometry (LC–MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography–Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and applications. As the technology itself has matured into a reliable analytical method over the last 15 years, the most exciting developments occur in LC–MS augments research into new applications. This edition places a stronger emphasis than previous editions on the impact of LC–MS methods, dedicating two-thirds of the text to small-molecule and biomolecular applications such as proteomics, pharmaceutical drug discovery and development, biochemistry, clinical analysis, environmental studies, and natural products research. Supported by the most relevant literature available, each chapter examines how the strategies, technologies, and recent advances—from sample pretreatment to data processing—in LC–MS helped to shape these disciplines. Featuring new chapters and extensive revisions throughout the book, Liquid Chromatography–Mass Spectrometry, Third Edition continues to provide scientists with a definitive guide and reference to the most important principles, strategies, and experimental precedents for applying LC–MS to their research.

Ion Mobility Spectrometry Third Edition

Author: G.A. Eiceman
Publisher: CRC Press
ISBN: 9781439859971
Release Date: 2013-12-10
Genre: Science

Since the turn of the twenty-first century, applications of ion mobility spectrometry (IMS) have diversified, expanding their utility in the military and security spheres and entering the realms of clinical practice and pharmaceutical exploration. Updated and expanded, the third edition of Ion Mobility Spectrometry begins with a comprehensive discussion of the fundamental theory and practice of IMS. Divided into four sections—Overview, Technology, Fundamentals, and Applications—the authors treat innovations and advances in all aspects of IMS in a fresh, thorough, and revised format. Features: Introduces the definitions, theory, and practice of IMS and summarizes its history from the beginnings of the study of ions to present commercial and scholarly activities Presents the technology of IMS from a measurement perspective—covering inlet through ion formation, ion injection, electric fields, drift tube structures, and detectors Covers the end results of measurement, the mobility spectrum, and the transformative trend of ion mobility: mass spectrometry Discusses the influence on the experimental parameters on the mobility of ions Mobility-based methods are no longer restricted to volatile substances and indeed the many benefits of this technology—simplicity, convenience, and the low cost of technology—have become recognized as meritorious in a wide range of uses. This is also true for the advantages of measurements—high speed, distinctive spectral features, and operation in ambient pressure with thermalized ions. Ion Mobility Spectrometry, Third Edition serves specialists in the field of IMS who are interested in the potential of recent developments and researchers, engineers, and students who want a comprehensive overview of this technology.

Encyclopedia of Spectroscopy and Spectrometry

Author:
Publisher: Academic Press
ISBN: 9780128032251
Release Date: 2016-09-22
Genre: Reference

This third edition of the Encyclopedia of Spectroscopy and Spectrometry provides authoritative and comprehensive coverage of all aspects of spectroscopy and closely related subjects that use the same fundamental principles, including mass spectrometry, imaging techniques and applications. It includes the history, theoretical background, details of instrumentation and technology, and current applications of the key areas of spectroscopy. The new edition will include over 80 new articles across the field. These will complement those from the previous edition, which have been brought up-to-date to reflect the latest trends in the field. Coverage in the third edition includes: Atomic spectroscopy Electronic spectroscopy Fundamentals in spectroscopy High-Energy spectroscopy Magnetic resonance Mass spectrometry Spatially-resolved spectroscopic analysis Vibrational, rotational and Raman spectroscopies The new edition is aimed at professional scientists seeking to familiarize themselves with particular topics quickly and easily. This major reference work continues to be clear and accessible and focus on the fundamental principles, techniques and applications of spectroscopy and spectrometry. Incorporates more than 150 color figures, 5,000 references, and 300 articles for a thorough examination of the field Highlights new research and promotes innovation in applied areas ranging from food science and forensics to biomedicine and health Presents a one-stop resource for quick access to answers and an in-depth examination of topics in the spectroscopy and spectrometry arenas

Liquid Chromatography

Author: Wilfried M.A. Niessen
Publisher: CRC Press
ISBN: 0824719360
Release Date: 1998-09-01
Genre: Science

This volume comprehensively relates developments, principles, and applications of combined liquid chromatography-mass spectrometry and other techniques such as capillary electrophoresis and supercritical fluid chromatography combined with mass spectrometry. It covers historical developments, currently important interfaces and technologies, and LC-MS applications in environmental analysis, pharmaceuticals and bioanalysis, and additional fields. It offers in-depth coverage of interfaces and technologies currently important in the laboratory, especially electrospray and APCI, contains an expanded applications section, and provides over 2200 references, tables, equations, and drawings.

Introduction to Mass Spectrometry

Author: J. Throck Watson
Publisher: John Wiley & Sons
ISBN: 9781118681589
Release Date: 2013-07-09
Genre: Science

Completely revised and updated, this text provides an easy-to-readguide to the concept of mass spectrometry and demonstrates itspotential and limitations. Written by internationally recognisedexperts and utilising "real life" examples of analyses andapplications, the book presents real cases of qualitative andquantitative applications of mass spectrometry. Unlike other massspectrometry texts, this comprehensive reference providessystematic descriptions of the various types of mass analysers andionisation, along with corresponding strategies for interpretationof data. The book concludes with a comprehensive 3000 references. This multi-disciplined text covers the fundamentals as well asrecent advance in this topic, providing need-to-know informationfor researchers in many disciplines including pharmaceutical,environmental and biomedical analysis who are utilizing massspectrometry

Annual Reports on NMR Spectroscopy

Author: Graham A. Webb
Publisher: Academic Press
ISBN: 9780123814340
Release Date: 2009-06-18
Genre: Science

Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. * Provides updates on the latest developments in NMR spectroscopy * Includes comprehensive review articles * Highlights the increasing importance of NMR spectroscopy as a technique for structural determination

Medical Applications of Mass Spectrometry

Author: Karoly Vekey
Publisher: Elsevier
ISBN: 9780080554655
Release Date: 2011-08-11
Genre: Science

Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine. The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry. * Guides the reader from basic principles and methods to cutting edge applications. * There is NO comparable book on the market to fill this fast growing field.

Chromatographic Analysis of the Environment Third Edition

Author: Leo M.L. Nollet
Publisher: CRC Press
ISBN: 9781420027983
Release Date: 2005-11-29
Genre: Science

Chromatographic Analysis of the Environment, Third Edition is a detailed handbook on different chromatographic analysis techniques and chromatographic data for compounds found in air, water, soil, and sludge. Taking on a new perspective from previous editions, this third edition discusses the parameters of each environmental compartment in a consistent format that highlights preparation techniques, chromatographic separation methods, and detection methods. Most of the data are compiled in tables and figures to elucidate the text as needed. Separate chapters approach specific aspects of sampling methods especially designed for environmental purposes, quantification of environmental analytes in difficult matrices, and data handling. The second part of the book focuses on the analysis of hazardous chemicals in the environment, including volatile organic carbons (VOCs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and endocrine-disrupting chemicals (EDCs). In addition, the authors feature information on compounds such as phosphates, organic acids, halogenated VOCs, amines, and n-ntirosamines, isocyanates, phthalate esters, and humic substances. Presenting important theoretical and practical aspects from sample collection to laboratory analysis, Chromatographic Analysis of the Environment, Third Edition is a unique resource of chromatographic techniques, data, and references that are useful to all scientists involved in the analysis of environmental compounds.

Practical Guide to ICP MS

Author: Robert Thomas
Publisher: CRC Press
ISBN: 9781466555433
Release Date: 2013-04-25
Genre: Science

Written by a field insider with over 20 years experience in product development, application support, and field marketing for an ICP-MS manufacturer, the third edition of Practical Guide to ICP-MS: A Tutorial for Beginners provides an updated reference that was written specifically with the novice in mind. It presents a compelling story about ICP-MS and what it has to offer, showing this powerful ultra trace-element technique in the way it was intended—a practical solution to real-world problems. New to the third edition: New chapter: Emerging ICP-MS Application Areas – covers the three most rapidly growing areas: analysis of flue gas desulfurization wastewaters, fully automated analysis of seawater samples using online chemistry procedures, and characterization of engineered nanoparticles Discussion of all the new technology commercialized since the second edition. An updated glossary of terms with more than 100 new entries Examination of nonstandard sampling accessories, which are important for enhancing the practical capabilities of ICP-MS Insight into additional applications in the environmental, clinical/biomedical, and food chemistry fields as well as new directives from the United States Pharmacopeia (USP) on determining impurities in pharmaceuticals and dietary supplements using Chapters 232, 233 and 2232 Description of the most important analytical factors for selecting an ICP-MS system, taking into consideration more recent application demands This reference describes the principles and application benefits of ICP-MS in a clear manner for laboratory managers, analytical chemists, and technicians who have limited knowledge of the technique. In addition, it offers much-needed guidance on how best to evaluate capabilities and compare with other trace element techniques when looking to purchase commercial ICP-MS instrumentation.

Practical Hydrogeology Principles and Field Applications Third Edition

Author: Willis D. Weight
Publisher: McGraw Hill Professional
ISBN: 9781260116908
Release Date: 2019-02-01
Genre: Technology & Engineering

Master the latest advances in hydrogeology using this fully updated resource This thoroughly revised guide clearly explains cutting-edge hydrogeology techniques that can be applied in the field. Featuring contributions from leading experts, Practical Hydrogeology: Principles and Field Applications, Third Edition, shows how to plan and conduct site investigations, avoid pitfalls in the field, interpret a wide array of data types gathered, and prepare water-quality reports. You will get complete coverage of key procedures, including aquifer testing, groundwater sampling, water-quality assessment, aquifer characterization, and tracer tests. This third edition has been reorganized and expanded with up-to-date information, a new chapter, review questions, and real-world examples. Coverage includes:•Field hydrogeology•The geology of hydrogeology•Aquifer properties•Groundwater flow•Pumping tests•Slug testing•Aquifer hydraulics•Water chemistry sampling•Groundwater/surface-water interaction•Vadose-zone analysis•Karst hydrogeology and tracer tests•Drilling and well completion

Aerosol Measurement

Author: Pramod Kulkarni
Publisher: John Wiley & Sons
ISBN: 1118001672
Release Date: 2011-09-09
Genre: Science

Aerosol Measurement: Principles, Techniques, and Applications Third Edition is the most detailed treatment available of the latest aerosol measurement methods. Drawing on the know-how of numerous expert contributors; it provides a solid grasp of measurement fundamentals and practices a wide variety of aerosol applications. This new edition is updated to address new and developing applications of aerosol measurement, including applications in environmental health, atmospheric science, climate change, air pollution, public health, nanotechnology, particle and powder technology, pharmaceutical research and development, clean room technology (integrated circuit manufacture), and nuclear waste management.

Thin Layer Chromatography in Phytochemistry

Author: Monika Waksmundzka-Hajnos
Publisher: CRC Press
ISBN: UVA:X030253372
Release Date: 2008-03-04
Genre: Science

Thin layer chromatography (TLC) is increasingly used in the fields of plant chemistry, biochemistry, and molecular biology. Advantages such as speed, versatility, and low cost make it one of the leading techniques used for locating and analyzing bioactive components in plants. Thin Layer Chromatography in Phytochemistry is the first source devoted to supplying state-of-the-art information on TLC as it applies to the separation, identification, quantification, and isolation of medicinal plant components. Renowned scientists working with laboratories around the world demonstrate the applicability of TLC to a remarkable diversity of fields including plant genetics, drug discovery, nutraceuticals, and toxicology. Elucidates the role of plant materials in the pharmaceutical industry... Part I provides a practical review of techniques, relevant materials, and the particular demands for using TLC in phytochemical applications. The text explains how to determine the biological activity of metabolites and assess the effectiveness of herbal medicines and nutritional supplements. Part II concentrates on TLC methods used to analyze specific plant-based metabolite classes such as carbohydrates, proteins, alkaloids, flavonoids, terpenes, etc. Organized by compound type, each chapter discusses key topics such as sample preparation, plate development, zone detection, densitometry, and biodetection. Demonstrates practical methods that can be applied to a wide range of disciplines... From identification to commercial scale production and quality control, Thin Layer Chromatography in Phytochemistry is an essential bench-top companion and reference on using TLC for the study of plant-based bioactive compounds.

Analyzing Biomolecular Interactions by Mass Spectrometry

Author: Jeroen Kool
Publisher: John Wiley & Sons
ISBN: 9783527673414
Release Date: 2015-02-09
Genre: Science

This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.