Medicinal Natural Products

Author: Paul M. Dewick
Publisher: John Wiley & Sons
ISBN: 9781119964575
Release Date: 2011-09-20
Genre: Science

Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Organische Chemie der biologischen Stoffwechselwege

Author: John McMurry
Publisher: Spektrum Akademischer Verlag
ISBN: 3827416574
Release Date: 2006-04-13
Genre: Science

Oftmals mangelt es an einem Verständnis der interdisziplinären Natur von Chemie und Biologie. Dies liegt zum Teil daran, dass ein geeignetes Lehrbuch für das Grund- und Hauptstudium fehlt, das die Grundlagen hierfür schafft und als Basis für weitere Diskussionen dienen kann. Ein neues Buch von John McMurry und Tadhg Begley, prominenten Wissenschaftlern auf dem Gebiet der organischen Chemie und der mechanistischen Enzymologie, schließt elegant diese Lücke. Rongson Pongdee und Hung-wen Liu in Chemistry and Biology 2005 Vierfarbig, grundlegend, klar gegliedert, einzigartig - Für wen ist das vierfarbige Lehrbuch geeignet? Für Studenten im Grund- und Hauptstudium aus allen Bereichen der Bioorganischen Chemie und der Biologischen Chemie sowie der Chemischen Biologie und der Biochemie. - Sind Vorkenntnisse erforderlich? Nein, nur Grundkenntnisse in organischer Chemie. - Wie gliedert sich das Buch? Nach den wichtigsten biochemischen Stoffwechselwegen mit ihren Reaktionsmechanismen und der zugrunde liegenden molekularen Logik, nach denen die Natur die Moleküle des Lebens ineinander umwandelt. Die wichtigsten Stoffwechselwege der verschiedenen Hauptklassen von Biomolekülen (Lipide, Kohlenhydrate, Aminosäuren und Nucleotide) werden vorgestellt und Themen wie Ionisierungszustände, Stereochemie, Prochiralität und andere wesentliche Merkmale der Struktur und Reaktivität verständlich erklärt.

Terpene

Author:
Publisher: Springer-Verlag
ISBN: 9783322947277
Release Date: 2013-04-17
Genre: Technology & Engineering


Physik des Segelns

Author: Wolfgang Püschl
Publisher: John Wiley & Sons
ISBN: 9783527648504
Release Date: 2012-09-10
Genre: Sports & Recreation

In dem Buch werden zun?chst einfache Grunds?tze und Bedingungen eingef?hrt wie Kr?ftegleichgewicht w?hrend der Fahrt. Dann wird aus den Eigenschaften von Luft und Wasser und den dynamischen Grundgleichungen das Entstehen dieser Kr?fte dargelegt. Von zun?chst zweidimensionaler Betrachtung wird systematisch zu dreidimensionalen Ph?nomenen vorgeschritten. Von Erscheinungen innerhalb des Mediums (Luft, Wasser) geht es in einem besonderen Kapitel zu den Erscheinungen an der Grenzfl?che, den Schwerewellen des Wassers und dem damit verbundenen Widerstand. Mit der Kenntnis aller Beitr?ge zur Vortriebsleistung wird erl?utert, wie sie aufeinander abgestimmt werden m?ssen, um optimal schnell zu segeln. Alle bisherigen ?berlegungen bezogen sich auf gleichm??ige Geschwindigkeit und gleichbleibende Lage des Segelboots. Nun werden zeitlich ver?nderliche Ph?nomene in Betracht gezogen wie Man?ver und das Arbeiten des Schiffs im Seegang. Zum Schluss wird, was f?r Bootskonstruktionen wichtig ist, die Materialfestigkeit unter statischen und dynamischen Bedingungen diskutiert.

Foye s Principles of Medicinal Chemistry

Author: Thomas L. Lemke
Publisher: Lippincott Williams & Wilkins
ISBN: 0781768799
Release Date: 2008
Genre: Medical

The Sixth Edition of this well-known text has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. Emphasis is on patient-focused pharmaceutical care and on the pharmacist as a therapeutic consultant, rather than a chemist. A new disease state management section explains appropriate therapeutic options for asthma, chronic obstructive pulmonary disease, and men's and women's health problems. Also new to this edition: Clinical Significance boxes, Drug Lists at the beginning of appropriate chapters, and an eight-page color insert with detailed illustrations of drug structures. Case studies from previous editions and answers to this edition's case studies are available online at thePoint.

Flavours and Fragrances

Author: Ralf Günter Berger
Publisher: Springer Science & Business Media
ISBN: 9783540493396
Release Date: 2007-03-06
Genre: Science

This book is an introduction to the world of aroma chemicals, essential oils, fragrances and flavour compositions for the food, cosmetics and pharmaceutical industry. Present technology, the future use of resources and biotechnological approaches for the production of the respective chemical compounds are described. The book has an integrated and interdisciplinary approach on future industrial production and the issues related to this topic.

Natural Product Chemistry for Drug Discovery

Author: Antony D. Buss
Publisher: Royal Society of Chemistry
ISBN: 9780854041930
Release Date: 2010
Genre: Medical

This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Plant derived Natural Products

Author: Anne E. Osbourn
Publisher: Springer Science & Business Media
ISBN: 0387854983
Release Date: 2009-07-07
Genre: Science

Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Fundamentals of Pharmacognosy and Phytotherapy E Book

Author: Michael Heinrich
Publisher: Elsevier Health Sciences
ISBN: 9780702052316
Release Date: 2012-04-25
Genre: Medical

‘A new classic’ in a new edition! Fully revised and updated throughout New sections on antimicrobials From journal reviews of the previous edition: ‘Drawing on their wealth of experience and knowledge in this field, the authors, who are without doubt among the finest minds in pharmacognosy today, provide useful and fascinating insights into the history, botany, chemistry, phytotherapy and importance of medicinal plants in some of today's health care systems. This is a landmark textbook, which carefully brings together relevant data from numerous sources and provides in an authoritative and exhaustive manner, cutting edge information that is relevant to pharmacists, pharmacognocists, complementary practitioners, doctors and nurses alike.’ The Pharmaceutical Journal ‘This is the first book that I have encountered which combines the compounds and plants found in standard pharmacognosy textbooks, i.e. those used in orthodox Western medicine, with the 'new phytopharmaceuticals' which have become established in Western culture over the last 20 years. The medical establishment in this environment is finally catching up with the practices of the general population and so this book is an excellent choice for those who wish to investigate which of the many plants available have some scientific credence. I shall be adding this book to the Essential Reading list for all of the undergraduate students on our pharmacy degree course and would encourage all those involved in teaching pharmacy students to do the same." P.J. Houghton, Department of Pharmacy, King's College London, Journal of Ethnopharmacology ‘Educated pharmacists no doubt equate Pharmacognosy with hours spent hunched over a microscope identifying vegetable drugs. Many probably consider it as a subject with little importance in a modern pharmacy curriculum. How wrong they are! ... This book is designed to give an overview at an easy-to-understand level of a broad subject area... For students of science and of the healthcare professions it is a useful text and the authors are to be commended for their work.’ Irish Pharmacy Journal From customer reviews: ‘A new classic. This is an excellent publication both for science students and the non scientific who have an interest in phytotherapy. The layout is logical and clearly set out. I love the chemical structural diagrams, and the explanations of even complex sequences are easy to understand with very little jargon. It is encouraging to see pharmacognosy being given a prominent place in a modern textbook, and interesting to see both hand drawings and chemical structures on the same page!’ ‘I can recommend this to anyone who is interested in the science behind herbal products and medicines; especially if you are interested in plants. It's quite simple to follow and very concise! Good for pharmacy students.’ ‘This is an ultimate textbook in this subject and a boon for students of M Pharmacy (Pharmacognosy) as well as undergraduates students of Pharmacy. Besides them, it is really suitable for every course comprising a study of plants and their medicinal use.’ ‘Excellent reference book. As an editor, I instantly found the answers to various questions I had regarding botanical descriptions. And it even answered questions that I hadn't gotten around to asking. Highly recommended!’

Biokatalysatoren und Enzymtechnologie

Author: Klaus Buchholz
Publisher: Wiley-Blackwell
ISBN: 3527282386
Release Date: 1997-01-30
Genre: Science

Dieses Buch vermittelt anschaulich und verständlich die Grundlagen der Enzymtechnologie. Der industrielle Einsatz von Enzymen gewinnt stetig an Bedeutung: in der Lebensmittelherstellung, bei der Synthese pharmazeutischer Wirkstoffe, bei der Nutzung in Waschmitteln, in der Analytik sowie in der Umwelttechnik. In didaktisch geeigneter Weise wird mit Hilfe von zahlreichen Anwendungsbeispielen die Verwendung von Enzymen als Biokatalysatoren für umweltverträgliche Stoffumwandlungen in der biotechnischen, Lebensmittel- und chemischen Industrie, im Umweltschutz und für analytische und diagnostische Zwecke erklärt. Die Themen im einzelnen: Einführung, Enzyme als Biokatalysatoren, Enzymproduktion und Aufarbeitung, Anwendung gelöster Enzyme, Immobilisierung von Enzymen, Immobilisierung von Mikroorganismen und Zellen, Charakterisierung immobilisierter Biokatalysatoren, Reaktoren und Prozeßtechnik, Analytische Anwendung von Enzymen.

Biogene Gifte

Author: Eberhard Teuscher
Publisher:
ISBN: 3804724388
Release Date: 2010-01
Genre:


Wirkstoffdesign

Author: Gerhard Klebe
Publisher: Springer-Verlag
ISBN: 9783827422132
Release Date: 2009-06-29
Genre: Medical

Dieses für den deutschen Raum einzigartige Lehrbuch richtet sich an Studenten der Pharmazie, Chemie und Biowissenschaften, aber auch an Quereinsteiger in Forschungs- und Entwicklungsabteilungen der Pharmazeutischen Industrie. Die zweite Auflage ist komplett überarbeitet. Zahlreiche aktuelle Entwicklungen vor allem im methodischen Bereich sind zum Teil in neuen Kapiteln aufgegriffen, viele Fallbeispiele machen die Theorien und Verfahren anschaulich und nachvollziehbar. Der Bogen spannt sich von der Geschichte der Arzneimittelforschung, den Wirkmechanismen der Arzneistoffe und den Methoden zur Leitstruktursuche und -optimierung über Strukturbestimmungsmethoden, Modelling, Moleküldynamik und QSAR-Methoden bis zum struktur- und computergestützten Design. Insgesamt legt das Buch besonderen Wert auf die räumliche Struktur der interagierenden Moleküle und erklärt, warum ein bestimmter Wirkstoff in seiner Gestalt praktisch durch die Geometrie und den Wirkmechanismus des Zielproteins festgelegt wird. Die beiliegende DVD mit interaktiven Molekülmodellen dient dem Ziel, dem Lernenden einen leichten Zugang zum räumlichen Verständnis der molekularen Strukturen und Interaktionen zu geben.

Bioactive Natural Products

Author: Goutam Brahmachari
Publisher: John Wiley & Sons
ISBN: 9783527684427
Release Date: 2015-01-20
Genre: Science

Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Encyclopedia of Food and Health

Author:
Publisher: Academic Press
ISBN: 9780123849533
Release Date: 2015-08-26
Genre: Technology & Engineering

The Encyclopedia of Food and Health provides users with a solid bridge of current and accurate information spanning food production and processing, from distribution and consumption to health effects. The Encyclopedia comprises five volumes, each containing comprehensive, thorough coverage, and a writing style that is succinct and straightforward. Users will find this to be a meticulously organized resource of the best available summary and conclusions on each topic. Written from a truly international perspective, and covering of all areas of food science and health in over 550 articles, with extensive cross-referencing and further reading at the end of each chapter, this updated encyclopedia is an invaluable resource for both research and educational needs. Identifies the essential nutrients and how to avoid their deficiencies Explores the use of diet to reduce disease risk and optimize health Compiles methods for detection and quantitation of food constituents, food additives and nutrients, and contaminants Contains coverage of all areas of food science and health in nearly 700 articles, with extensive cross-referencing and further reading at the end of each chapter