Polyhydroxyalkanoate (PHA) is a group of natural biopolymers synthesised by a wide variety of microbial genera. It is a biodegradable and biocompatible thermoplastic consisting of a repeated chain of various hydroxyalkanoate monomers.PHA is envisioned to be one of the most prospective and futuristic materials which is beneficial to mankind and to the world. In current world trends which concerns at the sustainable development from renewable and eco-friendly resources, PHA has garnered a growing attention as an alternative to petroleum based plastics.The book comes with two main objectives. In this book, major pipelines in processing this beneficial biopolymer were first reviewed from upstream to the downstream. The upstream processing includes the isolation of PHA producers, biosynthesis of PHA, genetic modification of PHA producers and optimisation of PHA production; meanwhile the downstream processing covers the PHA recovery and purification, degradation, quantification, characterisation, as well as the application of PHA. Readers will be exposed to the introductory information, along with some necessary concepts behind each subject.The second objective of this book is to provide readers with the recent advances on each PHA processing field. Being updated with the recent findings, this will provide an insight to readers on how the research trends for each subject are evolving from time to time. These updates will become useful case studies and quick references to readers from various areas, either from academia or industry.
Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market. Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry. To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input. Microbial Biopolyester Production, Performance and Processing: Microbiology, Feedstocks, and Metabolism encompasses eight chapters that cover aspects of the microbiology and biotechnology of producing biodegradable plastics. The contents focus on the selection of powerful archaeal and eubacterial production strains, genetic engineering as a tool for optimized PHA production and inexpensive carbon sources for microbial cultures. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production. Recent Advances in Biotechnology is a book series comprising of peer-reviewed reference works and monographs that compile the latest developments in the field of biotechnology. Each volume has a thematic focus and features topical reviews written by experts. The series will highlight multidisciplinary perspectives to interested readers (biotechnologists, microbiologists, bioprocess engineers, agronomists, medical professionals, sustainability researchers etc.)
Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market. Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry. To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input. Microbial Biopolyester Production, Performance and Processing: Bioengineering, Characterization, and Sustainability is a compilation of eight chapters covering bacterial polyesters, green plastics and PHAs from various angles. The contents of this volume focus on sustainable practices focus on the sustainability of processes that involve the synthesis and recycling of these meterials. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production.
Author: Syed Ali Ashter
Publisher: William Andrew
Release Date: 2017-11-22
Genre: Technology & Engineering
Technology and Applications of Polymers Derived from Biomass explores the range of different possible routes from biomass to polymeric materials, including the value and limitations of using biomass in material applications and a comparison of petrochemical-derived polymers and bio-based polymers. The book discusses biomass sources, types, chemistry and handling concerns. It covers the manufacture of industrial chemicals from biomass and the derivation of monomers and polymers from biomass. It also details the processing and applications of biomass-derived polymers to enable materials scientists and engineers realize the potential of biomass as a sustainable source of polymers, including plastics and elastomers. The book is a one-stop-shop reference—giving students a basic understanding of the technology and how the material can be applied to industrial processes they will face in the workforce, and giving materials engineers and product designers the information they need to make more informed material selection decisions. Provides fundamental understanding of an increasingly important approach to sourcing polymeric materials Includes actionable, relevant information to enable materials engineers and product designers consider biomass-derived polymers in the products they are developing Discusses the environmental impact of biomass conversion to help readers improve the sustainability of their operations Compares petrochemical-derived polymers with bio-based polymers
Author: George Guo-Qiang Chen
Publisher: Springer Science & Business Media
Release Date: 2009-12-02
Due to the possibility that petroleum supplies will be exhausted in the next decades to come, more and more attention has been paid to the production of bacterial pl- tics including polyhydroxyalkanoates (PHA), polylactic acid (PLA), poly(butylene succinate) (PBS), biopolyethylene (PE), poly(trimethylene terephthalate) (PTT), and poly(p-phenylene) (PPP). These are well-studied polymers containing at least one monomer synthesized via bacterial transformation. Among them, PHA, PLA and PBS are well known for their biodegradability, whereas PE, PTT and PPP are probably less biodegradable or are less studied in terms of their biodegradability. Over the past years, their properties and appli- tions have been studied in detail and products have been developed. Physical and chemical modifications to reduce their cost or to improve their properties have been conducted. PHA is the only biopolyester family completely synthesized by biological means. They have been investigated by microbiologists, molecular biologists, b- chemists, chemical engineers, chemists, polymer experts, and medical researchers for many years. PHA applications as bioplastics, fine chemicals, implant biomate- als, medicines, and biofuels have been developed. Companies have been est- lished for or involved in PHA related R&D as well as large scale production. It has become clear that PHA and its related technologies form an industrial value chain in fermentation, materials, feeds, and energy to medical fields.
Author: Basanta Kumara Behera
Release Date: 2017-08-09
This book describes how microbes can be used as effective and sustainable resources to meet the current challenge of finding suitable and economical solutions for biopharmaceuticals, enzymes, food additives, nutraceuticals, value added biochemicals and microbial fuels, and discusses various aspects of microbial regulatory activity and its applications. It particularly focuses on the design, layout and other relevant issues in industrial microbe applications. Moreover, it discusses the entire microbial-product supply chain, from manufacturing sites to end users, both in domestic and international markets, providing insights into the global marketing of microbes and microbial biomass-derived products. Further, it includes topics concerning the effective production and utilization of eco-friendly biotechnology industries. It offers a valuable, ready-to-use guide for technologists and policymakers developing new biotechnologies.
Bioprocessing for Value-Added Products from Renewable Resources provides a timely review of new and unconventional techniques for manufacturing high-value products based on simple biological material. The book discusses the principles underpinning modern industrial biotechnology and describes a unique collection of novel bioprocesses for a sustainable future. This book begins in a very structured way. It first looks at the modern technologies that form the basis for creating a bio-based industry before describing the various organisms that are suitable for bioprocessing - from bacteria to algae - as well as their unique characteristics. This is followed by a discussion of novel, experimental bioprocesses, such as the production of medicinal chemicals, the production of chiral compounds and the design of biofuel cells. The book concludes with examples where biological, renewable resources become an important feedstock for large-scale industrial production. This book is suitable for researchers, practitioners, students, and consultants in the bioprocess and biotechnology fields, and for others who are interested in biotechnology, engineering, industrial microbiology and chemical engineering. ·Reviews the principles underpinning modern industrial biotechnology ·Provides a unique collection of novel bioprocesses for a sustainable future ·Gives examples of economical use of renewable resources as feedstocks ·Suitable for both non-experts and experts in the bioproduct industry
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference
This book enables engineering students to understand how microbiology can be applied to environmental research and practical applications. Written specifically for senior undergraduate to graduate level civil and environmental engineering students, the textbook encompasses both fundamental and applied principles and covers topics such as the microbiology of water, wastewater, soil, and air biotreatment systems used in environmental engineering. It also covers civil engineering topics such as biocementation, biocorrosion, biofouling and biodeterioration of materials. Suitable for environmental engineers with little to no biology training, this book provides a thoroughly up-to-date introduction to current trends in environmental microbiology and engineering. Microbial classification is represented as a periodic table with theoretical connections between all prokaryotic groups and highlighting their environmental applications. The textbook includes quizzes for each chapter, tutorials and exam questions. A separate solutions manual is available with qualifying course adoption. Combining microbiological knowledge and environmental biotechnology principles in a readable fashion, the book includes topics such as Structures and functions of microbial cell and cell aggregates Applied microbial genetics and molecular biology Diversity and function of microorganisms in environmental engineering systems Environmental bioengineering processes Microbiological monitoring of environmental engineering systems Microbiology of water and wastewater treatment Biocementation and bioc1ogging of soil Biocorrosion of constructions Biodeterioration of materials Biopollution of indoor environment Bioremediation and biotransformation of solid waste and soil Ancillary Instructional Material: Quiz and Exam Bank As an instructor and an active participant in the environmental and civil engineering community, the author has recognized the need for field-specific microbiology instructional material, and has constructed a concise, relevant text for both students and professionals.
Current Developments in Biotechnology and Bioengineering: Production, Isolation and Purification of Industrial Products provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, focusing on industrial biotechnology and bioengineering practices for the production of industrial products, such as enzymes, organic acids, biopolymers, and biosurfactants, and the processes for isolating and purifying them from a production medium. During the last few years, the tools of molecular biology and genetic and metabolic engineering have rendered tremendous improvements in the production of industrial products by fermentation. Structured by industrial product classifications, this book provides an overview of the current practice, status, and future potential for the production of these agents, along with reviews of the industrial scenario relating to their production. Provides information on industrial bioprocesses for the production of microbial products by fermentation Includes separation and purification processes of fermentation products Presents economic and feasibility assessments of the various processes and their scaling up Links biotechnology and bioengineering for industrial process development
This contributed volume provides insights into multiple applications using microbes to promote productivity in agriculture, to produce biochemicals or to respond to challenges in biomedicine. It highlights the microbial production of nanocompounds with medical functionality alongside new anti-mycobacterial strategies, and introduces plant-growth-promoting Rhizobacteria as well as the correlation between biofilm formation and crop productivity. Further, the authors illustrate the green synthesis of biochemical compounds, such as hydroxamid acid or biosurfactants, using microbial and fungal enzymes. It inspires young researchers and experienced scientists in the field of microbiology to explore the combined use of green, white and red biotechnology for industrial purposes, which will be one of the central topics for future generations.
Biomass as Renewable Raw Material to Obtain Bioproducts of High-tech Value examines the use of biomass as a raw material, including terrestrial and aquatic sources to obtain extracts (e.g. polyphenols), biofuels, and/or intermediates (furfural, levulinates) through chemical and biochemical processes. The book also covers the production of natural polymers using biomass and the biosynthetic process, cellulose modified by biochemical and chemical methods, and other biochemicals that can be used in the synthesis of various pharmaceuticals. Featuring case studies, discussions of sustainability, and nanomedical, biomedical, and pharmaceutical applications, Biomass as Renewable Raw Material to Obtain Bioproducts of High-tech Value is a crucial resource for biotechnologists, biochemical engineers, biochemists, microbiologists, and research students in these areas, as well as entrepreneurs, policy makers, stakeholders, and politicians. Reviews biomass resources and compounds with bioactive properties Describes chemical and biochemical processes for creating biofuels from biomass Outlines production of polysaccharides and cellulose derivatives Features applications in the fields of medicine and pharmacy
Author: Stoyko Fakirov
Publisher: John Wiley & Sons
Release Date: 2015-04-06
Genre: Technology & Engineering
Collating otherwise hard-to-get and recently acquired knowledge in one work, this is a comprehensive reference on the synthesis, properties, characterization, and applications of this eco-friendly class of plastics. A group of internationally renowned researchers offer their first-hand experience and knowledge, dealing exclusively with those biodegradable polyesters that have become increasingly important over the past two decades due to environmental concerns on the one hand and newly-devised applications in the biomedical field on the other. The result is an unparalleled overview for the industrial chemist and materials scientist, as well as for developers and researchers in industry and academia alike.