Population Genetics

Author: John H. Gillespie
Publisher: JHU Press
ISBN: 1421401703
Release Date: 2010-12-29
Genre: Science

This book is indispensable for students working in a laboratory setting or studying free-ranging populations.

Population Genetics

Author: John H. Gillespie
Publisher: JHU Press
ISBN: 9780801880087
Release Date: 2004-06-28
Genre: Medical

This concise introduction addresses the theories behind population genetics and relevant empirical evidence, genetic drift, natural selection, nonrandom mating, quantitative genetics, and the evolutionary advantage of sex.

The Causes of Molecular Evolution

Author: John H. Gillespie
Publisher: Oxford University Press
ISBN: 0195357744
Release Date: 1994-05-26
Genre: Science

This work provides a unified theory that addresses the important problem of the origin and maintenance of genetic variation in natural populations. With modern molecular techniques, variation is found in all species, sometimes at astonishingly high levels. Yet, despite these observations, the forces that maintain variation within and between species have been difficult subjects of study. Because they act very weakly and operate over vast time scales, scientists must rely on indirect inferences and speculative mathematical models. However, despite these obstacles, many advances have been made. The author's research in molecular genetics, evolution, and bio-mathematics has enabled him to draw on this work, and present a coherent and valuable view of the field. The book is divided into three parts. The first consists of three chapters on protein evolution, DNA evolution, and molecular mechanisms. This section reviews the experimental observations on genetic variation. The second part gives a unified treatment of the mathematical theory of selection in a fluctuating environment. The final two chapters combine the earlier assessments in a treatment of the scientific status of two competing theories for the maintenance of genetic variation. Steeped in the enormous advances population genetics has made over the past 25 years, this book has proven highly popular among human geneticists, biologists, evolutionary theorists, and bio-mathematicians.

Elements of Evolutionary Genetics

Author: Brian Charlesworth
Publisher: Roberts Publishers
ISBN: STANFORD:36105215340113
Release Date: 2010
Genre: Science

Evolutionary genetics considers the causes of evolutionary change and the nature of variability in evolution. The methods of evolutionary genetics are critically important for the analysis and interpretation of the massive datasets on DNA sequence variation and evolution that are becoming available, as well for our understanding of evolution in general. This book shows readers how models of the genetic processes involved in evolution are made (including natural selection, migration, mutation, and genetic drift in finite populations), and how the models are used to interpret classical and molecular genetic data. The material is intended for advanced level undergraduate courses in genetics and evolutionary biology, graduate students in evolutionary biology and human genetics, and researchers in related fields who wish to learn evolutionary genetics. The topics covered include genetic variation, DNA sequence variability and its measurement, the different types of natural selection and their effects (e.g. the maintenance of variation, directional selection, and adaptation), the interactions between selection and mutation or migration, the description and analysis of variation at multiple sites in the genome, genetic drift, and the effects of spatial structure. The final two chapters demonstrate how the theory illuminates our understanding of the evolution of breeding systems, sex ratios and life histories, and some aspects of genome evolution.

Population Genetics and Microevolutionary Theory

Author: Alan R. Templeton
Publisher: John Wiley & Sons
ISBN: 9780470047217
Release Date: 2006-09-29
Genre: Science

The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links

Introduction to Population Genetics

Author: Richard Halliburton
Publisher: Benjamin-Cummings Publishing Company
ISBN: 0130163805
Release Date: 2004
Genre: Science

Making the theory of population genetics relevant to readers, this book explains the related mathematics with a logical organization.It presents the quantitative aspects of population genetics, and employs examples of human genetics, medical evolution, human evolution, and endangered species.For an introduction to, and understanding of, population genetics.

Understanding Population Genetics

Author: Torbjörn Säll
Publisher: John Wiley & Sons
ISBN: 9781119124030
Release Date: 2017-09-25
Genre: Science

Interpretations, extensions and comments -- Altruism and natural selection via individuals and groups -- Frequency-dependent selection and resource competition -- Rare allele advantage due to infections and self-incompatibility -- Questions -- Chapter 9 Selection on a quantitative trait -- Analysis -- Selection in quantitative genetics -- Selection in population genetics - one more time -- Notations and assumptions -- Combining the tools -- Summing up -- Interpretations, extensions and comments -- The genetic effect of selection on a quantitative trait -- The limits of selection and the nature of -- Threshold selection and disease liability -- Quantitative genetics is not suited for causal analyses -- Chapter 10 Evolutionary genetic analysis of the sex ratio -- Analysis -- Assumptions and notations -- Finding the recursion equation system -- Testing for stability -- Summing up -- Interpretations, extensions and comments -- Sex ratio selection -- An explanation of well-delimited validity -- Meiotic recombination is an evolved genetic system -- Evolutionary genetic analysis -- What's next? -- Estimates and tests in population genetics -- The mutation-selection balance -- Partial genetic isolation -- Segregation distortion and genetic conflicts -- Epilogue -- Thanks -- Glossary -- Answers -- References -- Index -- EULA

Handbook of Statistical Genetics

Author: David J. Balding
Publisher: John Wiley & Sons
ISBN: 0470997621
Release Date: 2008-06-10
Genre: Science

The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.

Genetics of Populations

Author: Philip W. Hedrick
Publisher: Jones & Bartlett Publishers
ISBN: 9781449656263
Release Date: 2011-08-24
Genre: Science

The Fourth Edition of Genetics of Populations is the most current, comprehensive, and accessible introduction to the field for advanced undergraduate and graduate students, and researchers in genetics, evolution, conservation, and related fields. In the past several years, interest in the application of population genetics principles to new molecular data has increased greatly, and Dr. Hedrick's new edition exemplifies his commitment to keeping pace with this dynamic area of study. Reorganized to allow students to focus more sharply on key material, the Fourth Edition integrates coverage of theoretical issues with a clear presentation of experimental population genetics and empirical data. Drawing examples from both recent and classic studies, and using a variety of organisms to illustrate the vast developments of population genetics, this text provides students and researchers with the most comprehensive resource in the field.

Molecular Population Genetics

Author: Matthew William Hahn
Publisher: Sinauer Associates, Incorporated
ISBN: 0878939652
Release Date: 2018
Genre:

Molecular Population Genetics is a general text covering one of the most active and exciting areas in biology. Combining advances in molecular biology and genomics with mathematical and empirical findings from population genetics, work in molecular population genetics has uncovered the extraordinary history of natural selection and demographic shifts in many organisms, including humans. While basic descriptions of the methods and tools of this field can be found in disparate places, no previous book has brought them together in a single volume. Rather than cobble together pieces from books, reviews, and primary research articles, Molecular Population Genetics presents a coherent user's guide to the field. Intended as a text for upper-level undergraduate and graduate students, the book will also be useful as a detailed reference for active professionals.

The Origins of Genome Architecture

Author: Michael Lynch
Publisher: Sinauer Associates Incorporated
ISBN: UOM:49015003406510
Release Date: 2007
Genre: Medical

The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features, yet often sacrificing simpler, more compelling explanations. This textbook explains why the details matter and presents an explanatory framework for how the architectural diversity of eukarotic genomes and genes came to arise. Presented in non-technical fashion, it is compatible for use in an advanced Genetics course and as a professional reference.

An Introduction to Population Genetics

Author: Rasmus Nielsen
Publisher: Sinauer Associates Incorporated
ISBN: 1605351539
Release Date: 2013
Genre: Science

"A text for a one-semester course in population genetics. It introduces students to classical population genetics (in terms of allele and haplotype frequencies) and modern population genetics (in terms of coalescent theory). It presents numerous applications of population genetic methods to practical problems, including testing for natural selection, detecting genetic hitchhiking and inferring the history of populations"--Provided by publisher.

Molecular Evolution and Phylogenetics

Author: Masatoshi Nei
Publisher: Oxford University Press
ISBN: 9780199881222
Release Date: 2000-07-27
Genre: Science

During the last ten years, remarkable progress has occurred in the study of molecular evolution. Among the most important factors that are responsible for this progress are the development of new statistical methods and advances in computational technology. In particular, phylogenetic analysis of DNA or protein sequences has become a powerful tool for studying molecular evolution. Along with this developing technology, the application of the new statistical and computational methods has become more complicated and there is no comprehensive volume that treats these methods in depth. Molecular Evolution and Phylogenetics fills this gap and present various statistical methods that are easily accessible to general biologists as well as biochemists, bioinformatists and graduate students. The text covers measurement of sequence divergence, construction of phylogenetic trees, statistical tests for detection of positive Darwinian selection, inference of ancestral amino acid sequences, construction of linearized trees, and analysis of allele frequency data. Emphasis is given to practical methods of data analysis, and methods can be learned by working through numerical examples using the computer program MEGA2 that is provided.

Mathematical Population Genetics 1

Author: Warren J. Ewens
Publisher: Springer Science & Business Media
ISBN: 9780387218229
Release Date: 2012-10-01
Genre: Science

This is the first of a planned two-volume work discussing the mathematical aspects of population genetics with an emphasis on evolutionary theory. This volume draws heavily from the author’s 1979 classic, but it has been revised and expanded to include recent topics which follow naturally from the treatment in the earlier edition, such as the theory of molecular population genetics.

Evolution in Age Structured Populations

Author: Brian Charlesworth
Publisher: Cambridge University Press
ISBN: 0521459672
Release Date: 1994-06-30
Genre: Mathematics

In this new edition, Brian Charlesworth provides a comprehensive review of the basic mathematical theory of the demography and genetics of age-structured populations. The author aims to avoid complicated mathematics, but gives full derivations of major theoretical results for the edification of the reader.