Advances in Cancer Stem Cell Biology

Author: Roberto Scatena
Publisher: Springer Science & Business Media
ISBN: 1461408091
Release Date: 2011-10-06
Genre: Medical

In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, head and neck, thyroid, cervix, lung, retina, colon, pancreas and so on). Cancer stem cells - rare cells with indefinite proliferative potential that drive the formation and growth of tumours- seem to show intriguing relationships with physiological stem cells. Specifically, these cancer cells show significant similarities in the mechanisms that regulate self-renewal of normal stem cells. Moreover, tumour cells might directly arise from normal stem cells. Further, the cellular biology of cancer stem cells show a lot of similarities with normal stem cells.

Energy Efficiency in Manufacturing Systems

Author: Sebastian Thiede
Publisher: Springer Science & Business Media
ISBN: 9783642259142
Release Date: 2012-04-23
Genre: Business & Economics

Energy consumption is of great interest to manufacturing companies. Beyond considering individual processes and machines, the perspective on process chains and factories as a whole holds major potentials for energy efficiency improvements. To exploit these potentials, dynamic interactions of different processes as well as auxiliary equipment (e.g. compressed air generation) need to be taken into account. In addition, planning and controlling manufacturing systems require balancing technical, economic and environmental objectives. Therefore, an innovative and comprehensive methodology – with a generic energy flow-oriented manufacturing simulation environment as a core element – is developed and embedded into a step-by-step application cycle. The concept is applied in its entirety to a wide range of case studies such as aluminium die casting, weaving mills, and printed circuit board assembly in order to demonstrate the broad applicability and the benefits that can be achieved.

Integrative Production Technology

Author: Christian Brecher
Publisher: Springer
ISBN: 9783319474526
Release Date: 2016-12-20
Genre: Technology & Engineering

This contributed volume contains the research results of the Cluster of Excellence “Integrative Production Technology for High-Wage Countries”, funded by the German Research Society (DFG). The approach to the topic is genuinely interdisciplinary, covering insights from fields such as engineering, material sciences, economics and social sciences. The book contains coherent deterministic models for integrative product creation chains as well as harmonized cybernetic models of production systems. The content is structured into five sections: Integrative Production Technology, Individualized Production, Virtual Production Systems, Integrated Technologies, Self-Optimizing Production Systems and Collaboration Productivity.The target audience primarily comprises research experts and practitioners in the field of production engineering, but the book may also be beneficial for graduate students.

Sustainable Manufacturing

Author: Rainer Stark
Publisher: Springer
ISBN: 9783319485140
Release Date: 2017-01-16
Genre: Technology & Engineering

This edited volume presents the research results of the Collaborative Research Center 1026 “Sustainable manufacturing - shaping global value creation”. The book aims at providing a reference guide of sustainable manufacturing for researchers, describing methodologies for development of sustainable manufacturing solutions. The volume is structured in four chapters covering the following topics: sustainable manufacturing technology, sustainable product development, sustainable value creation networks and systematic change towards sustainable manufacturing. The target audience comprises both researchers and practitioners in the field of sustainable manufacturing, but the book may also be beneficial for graduate students.

Bioreaction Engineering

Author: K. Schügerl
Publisher: Springer Science & Business Media
ISBN: 9783642597350
Release Date: 2012-12-06
Genre: Science

Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Proceedings of the 4th World Congress on Integrated Computational Materials Engineering ICME 2017

Author: Paul Mason
Publisher: Springer
ISBN: 9783319578644
Release Date: 2017-04-27
Genre: Technology & Engineering

This book represents a collection of papers presented at the 4th World Congress on Integrated Computational Materials Engineering (ICME 2017), a specialty conference organized by The Minerals, Metals & Materials Society (TMS). The contributions offer topics relevant to the global advancement of ICME as an engineering discipline. Topics covered include the following:ICME Success Stories and ApplicationsVerification, Validation, Uncertainty Quantification Issues and Gap AnalysisIntegration Framework and UsageAdditive ManufacturingPhase Field ModelingMicrostructure EvolutionICME Design Tools and ApplicationMechanical Performance Using Multi-Scale Modeling