A girl discovers her geneticist father is covering up multiple secrets—all of which are named Jason. Jason 3:3—known as Martyr—always believed his life had purpose. As one of the hundreds of clones living in a closed-off underground facility beneath an Alaskan farm, he has been told his genetics hold the key to saving humanity from an airborne pandemic aboveground, and his purpose will be filled on his upcoming eighteenth birthday. The problem is no such pandemic exists. Unaware of the truth, Martyr wishes for one glimpse of the sky before his expiration date arrives. His escape leads him to the home of one of the scientists, and to Abby Goyer. As she helps Martyr, she can’t help but notice his uncanny resemblance to the high school quarterback. Abby soon uncovers the dark truth behind Jason Farms and her dad’s work, and decides to show Martyr his true value and worth. As Martyr learns the truth behind his existence, he must decide if his God-given purpose is connected to the farm, or if it rests in a life with Abby.
Author: Arthur Kornberg
Publisher: University Science Books
Release Date: 2005
Often imitated but never rivalled, DNA Replication, regarded around the world as a classic of modern science, is now back in print in a paperback edition. Tania Baker and Nobel Prize-winner Arthur Kornberg's insightful coverage of DNA replication and related cellular processes have made this 1992 edition the standard reference in the field.
Author: Lynne Suzanne Cox
Publisher: Royal Society of Chemistry
Release Date: 2009
DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. An understanding of the process at both the biological and chemical level is essential to developing new techniques in molecular biology. Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. Rapidly dividing cells need to replicate their DNA prior to division, and targeting components of the replication process is a potentially powerful strategy in cancer treatment. Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. The fast pace of replication research, particularly in providing new structural insights, has outdated the majority of available texts. This learned, yet accessible, book contains the latest research written by those conducting it. It examines conserved themes providing a biological background for biochemical, chemical and pharmaceutical studies of this huge and exciting field. Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists. The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. Exciting potential drug targets in DNA replication are discussed, particularly in the context of treating malaria and cancer.
Author: J. Julian Blow
Publisher: Oxford University Press, USA
Release Date: 1996-09-26
A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge ofinterest in the subject.This book begins with reviews of the molecular and genetic components of the replication machinery, and builds up a picture of how the replication process is regulated within the cell division cycle.
Author: Bruce Alberts
Publisher: Garland Science
Release Date: 2017-08-07
As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Author: Ulrich Huebscher
Publisher: Springer Science & Business Media
Release Date: 2013-06-29
This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des cribed that are essential for this process: different DNA poly merases, DNA primases, DNA dependent ATPases, helicases, DNA liga ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.
This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters. Selected Contents: Base Excision Repair Eukaryotic DNA Mismatch Repair Double Strand Break Repair Functions of DNA Polymerases Somatic Hypermutation: A Mutational Panacea
Author: Roger Lionel Poulter Adams
Publisher: Oxford University Press, USA
Release Date: 1991-05-23
An understanding of the initiation of DNA replication holds the key to what controls cell division, growth and differentiation. This topic is central to studies in biochemistry, cell biology, genetics and molecular biology, but many textbooks have fallen behind the rapid developments in the field. This timely volume reviews most of the current understanding of replication in different organisms and provides details of exciting new findings. The book presents the general model for DNA replication, the various types of proteins involved, and the reactions occurring at the replication fork. Additional topics include alternative initiation mechanisms, replication control in organisms with single replicons, the significance of timing and direction of gene transcription, and various experimental approaches to studying eukaryotic origins. Termination signals and exciting new findings regarding telomere structure are investigated, followed by a consideration of how replicated DNA is packaged prior to cell division and how epigenetic information is conserved.
Author: Jennifer Trimble
Publisher: Cambridge University Press
Release Date: 2011-09-15
Why did Roman portrait statues, famed for their individuality, repeatedly employ the same body forms? The complex issue of the Roman copying of Greek 'originals' has so far been studied primarily from a formal and aesthetic viewpoint. Jennifer Trimble takes a broader perspective, considering archaeological, social historical and economic factors, and examines how these statues were made, bought and seen. To understand how Roman visual replication worked, Trimble focuses on the 'Large Herculaneum Woman' statue type, a draped female body particularly common in the second century CE and surviving in about two hundred examples, to assess how sameness helped to communicate a woman's social identity. She demonstrates how visual replication in the Roman Empire thus emerged as a means of constructing social power and articulating dynamic tensions between empire and individual localities.
Replication is a way of copying and updating information in a database. The Definitive Guide to SQL Server 2005 Replication is for Microsoft database developers and administrators who want to learn about the different types of replication and those best suited to SQL Server 2005. The book will also delve into advanced topics like replication of SQL Server with heterogeneous databases; replication of different database objects like stored procedures; backup and recovery of replicated databases; performance and tuning; and finally troubleshooting replication. As such, this book will address the concerns of both novice and advanced users of replication.
Replication and Transcription of Chromatin summarizes the main structural features of chromatin and presents results on replication and transcription gained over the last 20 years. The book emphasizes DNA-histone complexes and their importance in restricting genetic information encoded in DNA. Figures are used to illustrate many of the most important concepts of chromatin replication and transcription, and promising hypotheses and models are discussed to promote further research. Replication and Transcription of Chromatin is an important reference for biochemists, biophysicists, molecular biologists, cell biologists, and other researchers interested in this topic.