Author: Arthur Kornberg
Publisher: University Science Books
Release Date: 2005
Often imitated but never rivalled, DNA Replication, regarded around the world as a classic of modern science, is now back in print in a paperback edition. Tania Baker and Nobel Prize-winner Arthur Kornberg's insightful coverage of DNA replication and related cellular processes have made this 1992 edition the standard reference in the field.
A girl discovers her geneticist father is covering up multiple secrets—all of which are named Jason. Jason 3:3—known as Martyr—always believed his life had purpose. As one of the hundreds of clones living in a closed-off underground facility beneath an Alaskan farm, he has been told his genetics hold the key to saving humanity from an airborne pandemic aboveground, and his purpose will be filled on his upcoming eighteenth birthday. The problem is no such pandemic exists. Unaware of the truth, Martyr wishes for one glimpse of the sky before his expiration date arrives. His escape leads him to the home of one of the scientists, and to Abby Goyer. As she helps Martyr, she can’t help but notice his uncanny resemblance to the high school quarterback. Abby soon uncovers the dark truth behind Jason Farms and her dad’s work, and decides to show Martyr his true value and worth. As Martyr learns the truth behind his existence, he must decide if his God-given purpose is connected to the farm, or if it rests in a life with Abby.
Backup und Recovery sind mit die wichtigsten Aufgaben, die bei einer produktiven Umgebung anfallen. Hierbei spielt es keine Rolle, ob es sich um die virtuelle Welt handelt oder ob physische Systeme gesichert werden müssen. Auch eine Probewiederherstellung sollte zu den regelmäßigen Aufgaben eines jeden Administrators gehören. Im Falle eines Falles muss man sich auf ein Backup verlassen können, und man sollte dieses auch regelmäßig durch ein Recovery überprüfen oder über diese Software automatisiert durchführen lassen. In diesem Buch finden Sie Erläuterungen zu allen wichtigen Vorgehens- und Hinweisen zu deren richtiger Verwendung. Veeam Backup & Replication ist die Backup- und Replikationslösung für virtuelle und physische Maschinen mit Windows und Linux als Betriebssystem und VMware oder Hyper-V als Basis. Dieses Backup-Programm wurde nicht umsonst schon mehrfach ausgezeichnet. Es nimmt dem Benutzer die schwierigen Aufgaben ab und arbeitet im Hintergrund stabil und zuverlässig. Das Buch beginnt zunächst mit der Installation der Software und optionalen Komponenten sowie deren Voraussetzungen, behandelt alle wichtigen Einstellungs- und Konfigurationsmöglichkeiten der Software, gibt Hinweise und Tipps aus der Praxis, bietet Lösungsmöglichkeiten bei Problemen und erklärt Funktionen wie 3-2-1, GFS, synthetische Backups, Wiederherstellungsmöglichkeiten von AD, SQL, Oracle, Exchange sowie SharePoint, Einrichten von SureBackup Jobs und vieles mehr. Best Practices: Expertenwissen aus erster Hand Ralph Göpel ist Diplominformatiker, Microsoft Certified System Engineer und VMware Certified Professional. Er gibt Unterricht in den verschiedensten IT-Bereichen und Themen. Seit ca. 18 Jahren arbeitet er insbesondere als Consultant und Dozent mit den Produkten von VMware, seit einigen Jahren gehören die Produkte von Veeam mit dazu. Er unterstützt seine Kunden bei der Implementierung, macht Troubleshooting und übernimmt die Betreuung von kleinen bis großen Umgebungen.
This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Author: Roger Lionel Poulter Adams
Publisher: Oxford University Press, USA
Release Date: 1991-05-23
An understanding of the initiation of DNA replication holds the key to what controls cell division, growth and differentiation. This topic is central to studies in biochemistry, cell biology, genetics and molecular biology, but many textbooks have fallen behind the rapid developments in the field. This timely volume reviews most of the current understanding of replication in different organisms and provides details of exciting new findings. The book presents the general model for DNA replication, the various types of proteins involved, and the reactions occurring at the replication fork. Additional topics include alternative initiation mechanisms, replication control in organisms with single replicons, the significance of timing and direction of gene transcription, and various experimental approaches to studying eukaryotic origins. Termination signals and exciting new findings regarding telomere structure are investigated, followed by a consideration of how replicated DNA is packaged prior to cell division and how epigenetic information is conserved.
Author: Lynne Suzanne Cox
Publisher: Royal Society of Chemistry
Release Date: 2009
DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. An understanding of the process at both the biological and chemical level is essential to developing new techniques in molecular biology. Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. Rapidly dividing cells need to replicate their DNA prior to division, and targeting components of the replication process is a potentially powerful strategy in cancer treatment. Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. The fast pace of replication research, particularly in providing new structural insights, has outdated the majority of available texts. This learned, yet accessible, book contains the latest research written by those conducting it. It examines conserved themes providing a biological background for biochemical, chemical and pharmaceutical studies of this huge and exciting field. Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists. The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. Exciting potential drug targets in DNA replication are discussed, particularly in the context of treating malaria and cancer.
Author: Ulrich Huebscher
Publisher: Springer Science & Business Media
Release Date: 2013-06-29
This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des cribed that are essential for this process: different DNA poly merases, DNA primases, DNA dependent ATPases, helicases, DNA liga ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.
Enhanced by working code examples and illustrations of working systems, a comprehensive guide to the complex Oracle replication architecture and process covers such topics as the syntax for refresh intervals, snapshot log management, refresh timings, multimaster replication tuning and monitoring, and conflict resolution techniques. Original. (Advanced)
Author: Bernadette Charron-Bost
Publisher: Springer Science & Business Media
Release Date: 2010-03-02
Consistency models for replicated data /Alan D. Fekete and Krithi Ramamritham --Replication techniques for availability /Robbert van Renesse and Rachid Guerraoui --Modular approach to replication for availability /Fernando Pedone and André Schiper --Stumbling over consensus research: misunderstandings and issues /Marcos K. Aguilera --Replicating for performance: case studies /Maarten van Steen and Guillaume Pierre --A history of the virtual synchrony replication model /Ken Birman --From viewstamped replication to byzantine fault tolerance /Barbara Liskov --Implementing trustworthy services using replicated state machines /Fred B. Schneider and Lidong Zhou --State machine replication with Byzantine faults /Christian Cachin --Selected results from the latest decade of quorum systems research /Michael G. Merideth and Michael K. Reiter --From object replication to database replication /Fernando Pedone and André Schiper --Database replication: a tutorial /Dettina Kemme, Ricardo Jiménez-Peris, Marta Patiño-Martínez, and Gustavo Alonso --Practical database replication /Alfrânio Correia Jr. ...[et al.].
Author: J. Julian Blow
Publisher: Oxford University Press, USA
Release Date: 1996-09-26
A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge ofinterest in the subject.This book begins with reviews of the molecular and genetic components of the replication machinery, and builds up a picture of how the replication process is regulated within the cell division cycle.
Author: Luis Enjuanes
Publisher: Springer Science & Business Media
Release Date: 2006-03-30
Human coronaviruses caused the SARS epidemic that infected more than 8000 people, killing about ten percent of them in 32 countries. This book provides essential information on these viruses and the development of vaccines to control coronavirus infections.