Statistical Methods in Medical Research

Author: Peter Armitage
Publisher: John Wiley & Sons
ISBN: 9781118702581
Release Date: 2013-07-01
Genre: Medical

The explanation and implementation of statistical methods for themedical researcher or statistician remains an integral part ofmodern medical research. This book explains the use of experimentaland analytical biostatistics systems. Its accessible style allowsit to be used by the non-mathematician as a fundamental componentof successful research. Since the third edition, there have been many developments instatistical techniques. The fourth edition provides the medicalstatistician with an accessible guide to these techniques and toreflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to itssubject. There has been a radical reorganization of the text toimprove the continuity and cohesion of the presentation and toextend the scope by covering many new ideas now being introducedinto the analysis of medical research data. The authors have triedto maintain the modest level of mathematical exposition thatcharacterized the earlier editions, essentially confining themathematics to the statement of algebraic formulae rather thanpursuing mathematical proofs. Received the Highly Commended Certificate in the PublicHealth Category of the 2002 BMA BooksCompetition.

Tutorials in Biostatistics Statistical Methods in Clinical Studies

Author: Ralph B. D'Agostino
Publisher: John Wiley & Sons
ISBN: 9780470023662
Release Date: 2005-09-27
Genre: Mathematics

The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the first of two volumes presenting the best tutorials published in SIM, focusing on statistical methods in clinical studies. Topics include the design and analysis of clinical trials, epidemiology, survival analysis, and data monitoring. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.

Essential Statistical Methods for Medical Statistics

Author: J. Philip Miller
Publisher: Elsevier
ISBN: 0444537384
Release Date: 2010-11-08
Genre: Mathematics

Essential Statistical Methods for Medical Statistics presents only key contributions which have been selected from the volume in the Handbook of Statistics: Medical Statistics, Volume 27 (2009). While the use of statistics in these fields has a long and rich history, the explosive growth of science in general, and of clinical and epidemiological sciences in particular, has led to the development of new methods and innovative adaptations of standard methods. This volume is appropriately focused for individuals working in these fields. Contributors are internationally renowned experts in their respective areas. · Contributors are internationally renowned experts in their respective areas · Addresses emerging statistical challenges in epidemiological, biomedical, and pharmaceutical research · Methods for assessing Biomarkers, analysis of competing risks · Clinical trials including sequential and group sequential, crossover designs, cluster randomized, and adaptive designs · Structural equations modelling and longitudinal data analysis

Common Statistical Methods for Clinical Research with SAS Examples

Author: Glenn A. Walker
Publisher: SAS Institute
ISBN: 9781607644255
Release Date: 2010-02
Genre: Computers

Thoroughly updated edition of the popular introductory statistics book for clinical researchers. This new edition has been extensively updated to include the use of ODS graphics in numerous examples as well as a new emphasis on PROC MIXED.

Introduction to Statistical Methods for Clinical Trials

Author: Thomas D. Cook
Publisher: CRC Press
ISBN: 9781584880271
Release Date: 2007-11-19
Genre: Mathematics

Clinical trials have become essential research tools for evaluating the benefits and risks of new interventions for the treatment and prevention of diseases, from cardiovascular disease to cancer to AIDS. Based on the authors’ collective experiences in this field, Introduction to Statistical Methods for Clinical Trials presents various statistical topics relevant to the design, monitoring, and analysis of a clinical trial. After reviewing the history, ethics, protocol, and regulatory issues of clinical trials, the book provides guidelines for formulating primary and secondary questions and translating clinical questions into statistical ones. It examines designs used in clinical trials, presents methods for determining sample size, and introduces constrained randomization procedures. The authors also discuss how various types of data must be collected to answer key questions in a trial. In addition, they explore common analysis methods, describe statistical methods that determine what an emerging trend represents, and present issues that arise in the analysis of data. The book concludes with suggestions for reporting trial results that are consistent with universal guidelines recommended by medical journals. Developed from a course taught at the University of Wisconsin for the past 25 years, this textbook provides a solid understanding of the statistical approaches used in the design, conduct, and analysis of clinical trials.

Encyclopaedic Companion to Medical Statistics

Author: Brian S. Everitt
Publisher: John Wiley & Sons
ISBN: 9781119957409
Release Date: 2011-06-20
Genre: Medical

Statistical methodology is of great importance to medical research and clinical practice. The Encyclopaedic Companion to Medical Statistics contains readable accounts of the key topics central to current research and practice. Each entry has been written by an individual chosen for both their expertise in the field and their ability to communicate statistical concepts successfully to medical researchers. Real examples from the biomedical literature and relevant illustrations feature in many entries and extensive cross–referencing signposts the reader to related entries. Key Features: Contains accounts of over 400 statistical topics central to current medical research. 80% of first edition entries updated and revised. Presents the latest techniques used at the cutting edge of medical research. Covers common errors in statistical analyses in medicine. Real examples from the biomedical literature and relevant illustrations feature throughout. Contains contributions from over 70 experts in the field. Medical researchers, researchers and practitioners in medical research and statistics will benefit greatly from this book.

Practical Statistics for Medical Research

Author: Douglas G. Altman
Publisher: CRC Press
ISBN: 0412276305
Release Date: 1990-11-22
Genre: Mathematics

Most medical researchers, whether clinical or non-clinical, receive some background in statistics as undergraduates. However, it is most often brief, a long time ago, and largely forgotten by the time it is needed. Furthermore, many introductory texts fall short of adequately explaining the underlying concepts of statistics, and often are divorced from the reality of conducting and assessing medical research. Practical Statistics for Medical Research is a problem-based text for medical researchers, medical students, and others in the medical arena who need to use statistics but have no specialized mathematics background. The author draws on twenty years of experience as a consulting medical statistician to provide clear explanations to key statistical concepts, with a firm emphasis on practical aspects of designing and analyzing medical research. The text gives special attention to the presentation and interpretation of results and the many real problems that arise in medical research.

Regression Methods for Medical Research

Author: Bee Choo Tai
Publisher: John Wiley & Sons
ISBN: 9781118721988
Release Date: 2013-10-09
Genre: Medical

Regression Methods for Medical Research provides medical researchers with the skills they need to critically read and interpret research using more advanced statistical methods. The statistical requirements of interpreting and publishing in medical journals, together with rapid changes in science and technology, increasingly demands an understanding of more complex and sophisticated analytic procedures. The text explains the application of statistical models to a wide variety of practical medical investigative studies and clinical trials. Regression methods are used to appropriately answer the key design questions posed and in so doing take due account of any effects of potentially influencing co-variables. It begins with a revision of basic statistical concepts, followed by a gentle introduction to the principles of statistical modelling. The various methods of modelling are covered in a non-technical manner so that the principles can be more easily applied in everyday practice. A chapter contrasting regression modelling with a regression tree approach is included. The emphasis is on the understanding and the application of concepts and methods. Data drawn from published studies are used to exemplify statistical concepts throughout. Regression Methods for Medical Research is especially designed for clinicians, public health and environmental health professionals, para-medical research professionals, scientists, laboratory-based researchers and students.

Advanced Medical Statistics

Author: Ying Lu
Publisher: World Scientific
ISBN: 9810248008
Release Date: 2003
Genre: Medical

This book presents new and powerful advanced statistical methods that have been used in modern medicine, drug development, and epidemiology. Some of these methods were initially developed for tackling medical problems. All 29 chapters are self-contained. Each chapter represents the new development and future research topics for a medical or statistical branch. For the benefit of readers with different statistical background, each chapter follows a similar style: the explanation of medical challenges, statistical ideas and strategies, statistical methods and techniques, mathematical remarks and background and reference. All chapters are written by experts of the respective topics.

Statistical Methods for Clinical Trials

Author: Mark X. Norleans
Publisher: CRC Press
ISBN: 0824704673
Release Date: 2000-11-08
Genre: Mathematics

"Summarizes graphical analysis, analysis of variance, meta-analysis, and design of comparable treatment groups. Streamlines the analytical techniques for continuous, categorical, longitudinal, and survival data-focusing on generalized linear models, GEEs, and mixed linear models, -ahd highlihgts p-value, and more."

Medical Uses of Statistics

Author: John C. Bailar
Publisher: John Wiley & Sons
ISBN: 9781118211182
Release Date: 2012-01-10
Genre: Medical

A new edition of the classic guide to the use of statistics inmedicine, featuring examples from articles in the New EnglandJournal of Medicine Medical Uses of Statistics has served as one of the mostinfluential works on the subject for physicians,physicians-in-training, and a myriad of healthcare experts who needa clear idea of the proper application of statistical techniques inclinical studies as well as the implications of theirinterpretation for clinical practice. This Third Editionmaintains the focus on the critical ideas, rather than themechanics, to give practitioners and students the resources theyneed to understand the statistical methods they encounter in modernmedical literature. Bringing together contributions from more than two dozendistinguished statisticians and medical doctors, this volumestresses the underlying concepts in areas such as randomizedtrials, survival analysis, genetics, linear regression,meta-analysis, and risk analysis. The Third Editionincludes: Numerous examples based on studies taken directly from the pagesof the New England Journal ofMedicine Two added chapters on statistics in genetics Two new chapters on the application of statistical methods tostudies in epidemiology New chapters on analyses of randomized trials, linearregression, categorical data analysis, meta-analysis, subgroupanalyses, and risk analysis Updated chapters on statistical thinking, crossover designs,p-values, survival analysis, and reporting research results A focus on helping readers to critically interpret publishedresults of clinical research Medical Uses of Statistics, Third Edition is a valuableresource for researchers and physicians working in anyhealth-related field. It is also an excellent supplemental book forcourses on medicine, biostatistics, and clinical research at theupper-undergraduate and graduate levels. You can also visit the NewEngland Journal of Medicine website for relatedinformation.