In the summer of 1998 two of baseball leading sluggers, Mark McGwire and Sammy Sosa, embarked on a race to break Babe Ruth’s single season home run record. The nation was transfixed as Sosa went on to hit 66 home runs, and McGwire 70. Three years later, San Francisco Giants All-Star Barry Bonds surpassed McGwire by 3 home runs in the midst of what was perhaps the greatest offensive display in baseball history. Over the next three seasons, as Bonds regularly launched mammoth shots into the San Francisco Bay, baseball players across the country were hitting home runs at unprecedented rates. For years there had been rumors that perhaps some of these players owed their success to steroids. But crowd pleasing homers were big business, and sportswriters, fans, and officials alike simply turned a blind eye. Then, in December of 2004, after more than a year of investigation, San Francisco Chronicle reporters Mark Fainaru-Wada and Lance Williams broke the story that in a federal investigation of a nutritional supplement company called BALCO, Yankees slugger Jason Giambi had admitted taking steroids. Barry Bonds was also implicated. Immediately the issue of steroids became front page news. The revelations led to Congressional hearings on baseball’s drug problems and continued to drive the effort to purge the U.S. Olympic movement of drug cheats. Now Fainaru-Wada and Williams expose for the first time the secrets of the BALCO investigation that has turned the sports world upside down. Game of Shadows: Barry Bonds, BALCO, and the Steroid Scandal That Rocked Professional by award-winning investigative journalists Mark Fainaru-Wada and Lance Williams, is a riveting narrative about the biggest doping scandal in the history of sports, and how baseball’s home run king, Barry Bonds of the San Francisco Giants, came to use steroids. Drawing on more than two years of reporting, including interviews with hundreds of people, and exclusive access to secret grand jury testimony, confidential documents, audio recordings, and more, the authors provide, for the first time, a definitive account of the shocking steroids scandal that made headlines across the country. The book traces the career of Victor Conte, founder of the BALCO laboratory, an egomaniacal former rock musician and self-proclaimed nutritionist, who set out to corrupt sports by providing athletes with “designer” steroids that would be undetectable on “state-of-the-art” doping tests. Conte gave the undetectable drugs to 28 of the world’s greatest athletes—Olympians, NFL players and baseball stars, Bonds chief among them. A separate narrative thread details the steroids use of Bonds, an immensely talented, moody player who turned to performance-enhancing drugs after Mark McGwire of the St. Louis Cardinals set a new home run record in 1998. Through his personal trainer, Bonds gained access to BALCO drugs. All of the great athletes who visited BALCO benefited tremendously—Bonds broke McGwire’s record—but many had their careers disrupted after federal investigators raided BALCO and indicted Conte. The authors trace the course of the probe, and the baffling decision of federal prosecutors to protect the elite athletes who were involved. Highlights of Game of Shadows include: Barry Bonds A look at how Bonds was driven to use performance-enhancing drugs in part by jealousy over Mark McGwire’s record-breaking 1998 season. It was shortly thereafter that Bonds—who had never used anything more performance enhancing than a protein shake from the health food store—first began using steroids. How Bonds’s weight trainer, steroid dealer Greg Anderson, arranged to meet Victor Conte before the 2001 baseball season with...
Author: Sean B. Carroll
Publisher: Broadway Books
Release Date: 2013
Genre: Biography & Autobiography
Traces the friendship and collaborative achievements of 20th-century intellectuals Albert Camus and Jacques Monod, discussing their contributions to the French Resistance, Nobel Prize-winning work and passionate advocacy of human rights.
From Jeanne Guillemin, one of the world's leading experts on anthrax and bioterrorism, the definitive account of the anthrax investigation It was the most complex case in FBI history. In what became a seven-year investigation that began shortly after 9/11—with America reeling from the terror attacks of al Qaeda—virulent anthrax spores sent through the mail killed Bob Stevens, a Florida tabloid photo editor. His death and, days later, the discovery in New York and Washington, D.C. of letters filled with anthrax sent shock waves through the nation. Federal agencies were blindsided by the attacks, which eventually killed five people. Taken off guard, the FBI struggled to combine on-the-ground criminal investigation with progress in advanced bioforensic analyses of the letters' contents. While the criminal eluded justice, disinformation swirled around the letters, erroneously linking them to Iraq's WMD threat and foreign bioterrorism. Without oversight, billions were lavished on biomedical defenses against anthrax and other exotic diseases. Worst of all, faith in federal justice faltered. American Anthrax is a gripping tale of terror, intrigue, madness, and cover-up.
Author: Robert Klitzman
Publisher: Oxford University Press, USA
Release Date: 2015
Research on human beings saves countless lives, but has at times harmed the participants. To what degree then should government regulate science, and how? The horrors of Nazi concentration camp experiments and the egregious Tuskegee syphilis study led the US government, in 1974, to establish Research Ethics Committees, known as Institutional Review Boards (IRBs) to oversee research on humans. The US now has over 4,000 IRBs, which examine yearly tens of billions of dollars of research -- all studies on people involving diseases, from cancer to autism, and behavior. Yet ethical violations persist. At the same time, critics have increasingly attacked these committees for delaying or blocking important studies. Partly, science is changing, and the current system has not kept up. Since the regulations were first conceived 40 years ago, research has burgeoned 30-fold. Studies often now include not a single university, but multiple institutions, and 40 separate IRBs thus need to approve a single project. One committee might approve a study quickly, while others require major changes, altering the scientific design, and making the comparison of data between sites difficult. Crucial dilemmas thus emerge of whether the current system should be changed, and if so, how. Yet we must first understand the status quo to know how to improve it. Unfortunately, these committees operate behind closed doors, and have received relatively little in-depth investigation. Robert Klitzman thus interviewed 45 IRB leaders and members about how they make decisions. What he heard consistently surprised him. This book reveals what Klitzman learned, providing rare glimpses into the conflicts and complexities these individuals face, defining science, assessing possible future risks and benefits of studies, and deciding how much to trust researchers -- illuminating, more broadly, how we view and interpret ethics in our lives today, and perceive and use power. These committees reflect many of the most vital tensions of our time - concerning science and human values, individual freedom, government control, and industry greed. Ultimately, as patients, scientists, or subjects, the decisions of these men and women affect us all.
"In an age of creative and intellectual specialisation Carl Djerassi stands out for his virtuosity in both science and the arts. His transition, at a time of life when many men are thinking about retirement, from being a star organic chemist to being a writer of fiction, poetry, novels and plays which have been published and translated and performed all round the world, is surely unique. This final installment of autobiography is deeply expressive of the man: feisty, witty, candid, totally committed to the life of the mind yet susceptible to powerful emotions triggered by love and death, and humorously, but unapologetically, aware of his own driven nature."David LodgeNovelist, critic and Emeritus Professor of English Literature, University of Birmingham"Carl Djerassi is a great scientist who has rare skill as a creative writer as well as a deep interest in the arts, in education and in global issues. This wide-ranging book, written reflectively and with great eloquence, would fascinate scientists and non-scientists alike and deserves a very broad readership."Lord Martin ReesAstronomer Royal and former President of the Royal Society"Carl Djerassi, novelist, playwright, poet and memoirist, is a writer of exceptional versatility who brings his scientific, historical and literary knowledge to a dazzling range of themes. He is not afraid of big ideas or of personal issues and animates them with wit and invention."Dame Margaret DrabbleNovelist, biographer and criticThese are the reflections of a nonagenarian polymath describing the shift from a fifty-year-long career as a world-famous chemist to a subsequent twenty-five-year immersion in "science-in-fiction" and "science-in-theater, " which is virtually unique among contemporary scientists. Sharply self-critical, yet full of humor, this autobiographical account covers themes such as the future of sex in an age of technological reproduction, the history of the Pill seen through the eyes of one of its inventors, innovative -- even unique -- pedagogic experiments, the insoluble homelessness of a refugee, suicide, and art collecting. This book is also heavily illustrated with 94 individual pictures.
Author: Suzanne Bourgeois
Publisher: Univ of California Press
Release Date: 2013-09-20
This work is a personal account of the origins and early years of the Salk Institute for Biological Studies. Bourgeois crafts an engaging study that draws on her involvement with the Institute and on related archives, interviews, and informal conversations. The volume discusses the people who founded the Institute and built a home for renowned research—leading scientists of the time as well as non-scientists of stature in finance, politics, philanthropy, publishing, and the humanities. The events that brought people together, the historic backdrop in which they worked, their personalities, their courage and their visions, their clash of egos and their personal vanities are woven together in a rich, engaging narrative about the founding of a world-premier research institution.
Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
An influential geneticist traces his investigation into the genes of humanity's closest evolutionary relatives, explaining what his sequencing of the Neanderthal genome has revealed about their extinction and the origins of modern humans.
Author: Protasio Lemos Da Luz
Publisher: Academic Press
Release Date: 2018-02-03
Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes
Author: Victor J. Stenger
Publisher: Prometheus Books
Release Date: 2010-08-05
Throughout history, arguments for and against the existence of God have been largely confined to philosophy and theology, while science has sat on the sidelines. Despite the fact that science has revolutionized every aspect of human life and greatly clarified our understanding of the world, somehow the notion has arisen that it has nothing to say about the possibility of a supreme being, which much of humanity worships as the source of all reality. This book contends that, if God exists, some evidence for this existence should be detectable by scientific means, especially considering the central role that God is alleged to play in the operation of the universe and the lives of humans. Treating the traditional God concept, as conventionally presented in the Judeo-Christian and Islamic traditions, like any other scientific hypothesis, physicist Stenger examines all of the claims made for God's existence. He considers the latest Intelligent Design arguments as evidence of God's influence in biology. He looks at human behavior for evidence of immaterial souls and the possible effects of prayer. He discusses the findings of physics and astronomy in weighing the suggestions that the universe is the work of a creator and that humans are God's special creation. After evaluating all the scientific evidence, Stenger concludes that beyond a reasonable doubt the universe and life appear exactly as we might expect if there were no God. This paperback edition of the New York Times bestselling hardcover edition contains a new foreword by Christopher Hitchens and a postscript by the author in which he responds to reviewers' criticisms of the original edition. From the Trade Paperback edition.
Author: P. Conn
Release Date: 2008-05-12
Genre: Political Science
This thoughtful and surprising book analyzes the effect of animal extremism on the world's scientists, their institutions, and professional societies. The Animal Research War traces the evolution of the animal rights movement, profiles its leadership, and reveals the truth behind university animal research.
Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.