The Gene

Author: Siddhartha Mukherjee
Publisher: Simon and Schuster
ISBN: 9781476733531
Release Date: 2016-05-17
Genre: Medical

THE #1 NEW YORK TIMES BESTSELLER A New York Times Notable Book A Washington Post and Seattle Times Best Book of the Year From the Pulitzer Prize-winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

The Gene

Author: Siddhartha Mukherjee
Publisher: Random House
ISBN: 9781448181162
Release Date: 2016-06-02
Genre: Science

Selected as a Book of the Year by The New York Times, The Economist, Independent, Observer and Mail on Sunday THE NEW YORK TIMES NUMBER ONE BESTSELLER BBC RADIO 4 BOOK OF THE WEEK ‘Dramatic and precise... [A] thrilling and comprehensive account of what seems certain to be the most radical, controversial and, to borrow from the subtitle, intimate science of our time... He is a natural storyteller... A page-turner... Read this book and steel yourself for what comes next’ Bryan Appleyard, Sunday Times The Gene is the story of one of the most powerful and dangerous ideas in our history, from bestselling, prize-winning author Siddhartha Mukherjee. Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. This is an epic, moving history of a scientific idea coming to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history – the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to “read” and “write” the human genome – unleashing the potential to change the fates and identities of our children. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856 where a monk stumbles on the idea of a ‘unit of heredity’. It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. This is a story driven by human ingenuity and obsessive minds – from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity – and a vision of both humanity’s past and future.

The Gene

Author: Siddhartha Mukherjee
Publisher: Penguin UK
ISBN: 9789386057051
Release Date: 2016-05-17
Genre: Science

Spanning the globe and several centuries, The Gene is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. The story of the gene begins in an obscure Augustinian abbey in Moravia in 1856, where a monk stumbles on the idea of a ‘unit of heredity’. It intersects with Darwin’s theory of evolution, and collides with the horrors of Nazi eugenics in the 1940s. The gene transforms post-war biology. It reorganizes our understanding of sexuality, temperament, choice and free will. Above all, this is a story driven by human ingenuity and obsessive minds–from Charles Darwin and Gregor Mendel to Francis Crick, James Watson and Rosalind Franklin, and the thousands of scientists still working to understand the code of codes. This is an epic, moving history of a scientific idea being brought to life, by the author of The Emperor of All Maladies. But woven through The Gene, like a red line, is also an intimate history–the story of Mukherjee’s own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives. These concerns reverberate even more urgently today as we learn to ‘read’ and ‘write’ the human genome–unleashing the potential to change the fates and identities of our children. Majestic in its ambition, and unflinching in its honesty, The Gene gives us a definitive account of the fundamental unit of heredity–and a vision of both humanity’s past and future.

The Gene Machine

Author: Bonnie Rochman
Publisher: Scientific American / Farrar, Straus and Giroux
ISBN: 9780374713966
Release Date: 2017-02-28
Genre: Family & Relationships

A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.

The Century of the Gene

Author: Evelyn Fox KELLER
Publisher: Harvard University Press
ISBN: 0674039432
Release Date: 2009-06-30
Genre: Science

In a book that promises to change the way we think and talk about genes and genetic determinism, Evelyn Fox Keller, one of our most gifted historians and philosophers of science, provides a powerful, profound analysis of the achievements of genetics and molecular biology in the twentieth century, the century of the gene. Not just a chronicle of biology's progress from gene to genome in one hundred years, "The Century of the Gene" also calls our attention to the surprising ways these advances challenge the familiar picture of the gene most of us still entertain. Keller shows us that the very successes that have stirred our imagination have also radically undermined the primacy of the gene--word and object--as the core explanatory concept of heredity and development. She argues that we need a new vocabulary that includes concepts such as robustness, fidelity, and evolvability. But more than a new vocabulary, a new awareness is absolutely crucial: that understanding the components of a system (be they individual genes, proteins, or even molecules) may tell us little about the interactions among these components. With the Human Genome Project nearing its first and most publicized goal, biologists are coming to realize that they have reached not the end of biology but the beginning of a new era. Indeed, Keller predicts that in the new century we will witness another Cambrian era, this time in new forms of biological thought rather than in new forms of biological life.

Summary and Analysis of The Gene An Intimate History

Author: Worth Books
Publisher: Open Road Media
ISBN: 9781504043380
Release Date: 2016-12-13
Genre: Study Aids

So much to read, so little time? This brief overview of The Gene tells you what you need to know—before or after you read Siddhartha Mukherjee’s book. Crafted and edited with care, Worth Books set the standard for quality and give you the tools you need to be a well-informed reader. This short summary and analysis of The Gene by Siddhartha Mukherjee includes: Historical context Chapter-by-chapter summaries Detailed timeline of key events Important quotes Fascinating trivia Glossary of terms Supporting material to enhance your understanding of the original work About Siddhartha Mukherjee’s The Gene: From the Pulitzer Prize–winning author of The Emperor of All Maladies, The Gene is a rigorously scientific, broadly historical, and candidly personal account of the development of the science of genetics, the dramatic ways genes can affect us, and the enormous moral questions posed by our ability to manipulate them. As Siddhartha Mukherjee maps out the fascinating biography of the gene, from research and experimentation to scientific breakthroughs, he always returns to the narrative of his own family’s tragic history of mental illness, reminding us that despite our huge leaps in knowledge, there is still much we do not understand about the incredibly complex human genome. The Gene is an important read for anyone concerned about a future that may redefine what it means to be human. The summary and analysis in this ebook are intended to complement your reading experience and bring you closer to a great work of nonfiction.

The Gene

Author: Ted Everson
Publisher: Greenwood Publishing Group
ISBN: 0313334498
Release Date: 2007
Genre: Science

A history of the science of genetics discusses its roots in heredity, the discovery of DNA, the Human Genome Project, the applications of genetic work, and the controversy surrounding genetic engineering.

The Gene

Author: Instaread
Publisher: Instaread
ISBN: 9781683783701
Release Date: 2016-06-24
Genre: Science

The Gene by Siddhartha Mukherjee | Summary & Analysis Preview: The Gene by Siddhartha Mukherjee describes the history of genetic research, the impact of genetic inheritance on his family, and the potential for future applications of gene science. Mukherjee’s father and uncles struggled with disorders such as schizophrenia and bipolar disorder, both of which are linked to genetic mutations. After centuries of conjecture about the nature of familial inheritance, naturalist Charles Darwin published his theory of evolution in 1859. In 1865, botanist Gregor Mendel proposed that genetic information is passed down from both the paternal and maternal sides of the family in the form of paired genes. Thereafter, eugenics gradually became socially accepted and programs to sterilize the disabled and deviant were established in the United States. The practice of eugenics became socially abhorrent following World War II and the revelations of genocidal practices in Nazi Germany and Stalinist Russia. Between 1908 and 1963, scientists continued studying genetic material… PLEASE NOTE: This is key takeaways and analysis of the book and NOT the original book. Inside this Instaread Summary of The Gene · Overview of the Book · Important People · Key Takeaways · Analysis of Key Takeaways The Gene by Siddhartha Mukherjee | Summary & Analysis Preview: The Gene by Siddhartha Mukherjee describes the history of genetic research, the impact of genetic inheritance on his family, and the potential for future applications of gene science. Mukherjee’s father and uncles struggled with disorders such as schizophrenia and bipolar disorder, both of which are linked to genetic mutations. After centuries of conjecture about the nature of familial inheritance, naturalist Charles Darwin published his theory of evolution in 1859. In 1865, botanist Gregor Mendel proposed that genetic information is passed down from both the paternal and maternal sides of the family in the form of paired genes. Thereafter, eugenics gradually became socially accepted and programs to sterilize the disabled and deviant were established in the United States. The practice of eugenics became socially abhorrent following World War II and the revelations of genocidal practices in Nazi Germany and Stalinist Russia. Between 1908 and 1963, scientists continued studying genetic material… PLEASE NOTE: This is key takeaways and analysis of the book and NOT the original book. Inside this Instaread Summary of The Gene: · Overview of the Book · Important People · Key Takeaways · Analysis of Key Takeaways About the Author With Instaread, you can get the key takeaways, summary and analysis of a book in 15 minutes. We read every chapter, identify the key takeaways and analyze them for your convenience.

The Sports Gene

Author: David Epstein
Publisher: Penguin
ISBN: 9781101622636
Release Date: 2013-08-01
Genre: Sports & Recreation

The New York Times bestseller – with a new afterword about early specialization in youth sports. The debate is as old as physical competition. Are stars like Usain Bolt, Michael Phelps, and Serena Williams genetic freaks put on Earth to dominate their respective sports? Or are they simply normal people who overcame their biological limits through sheer force of will and obsessive training? In this controversial and engaging exploration of athletic success and the so-called 10,000-hour rule, David Epstein tackles the great nature vs. nurture debate and traces how far science has come in solving it. Through on-the-ground reporting from below the equator and above the Arctic Circle, revealing conversations with leading scientists and Olympic champions, and interviews with athletes who have rare genetic mutations or physical traits, Epstein forces us to rethink the very nature of athleticism.

Molecular Biology of the Gene

Author: James D. Watson
Publisher: Benjamin-Cummings Publishing Company
ISBN: 0321762436
Release Date: 2014
Genre: Medical

Now completely up-to-date with the latest research advances, the Seventh Edition retains the distinctive character of earlier editions. Twenty-two concise chapters, co-authored by six highly distinguished biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.

p53

Author: Sue Armstrong
Publisher: Bloomsbury Publishing
ISBN: 9781472910530
Release Date: 2014-11-20
Genre: Health & Fitness

All of us have lurking in our DNA a most remarkable gene, which has a crucial job ? it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures ? the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge. This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives.

The Selfish Gene

Author: Richard Dawkins
Publisher: Oxford University Press, USA
ISBN: 0192860925
Release Date: 1989
Genre: Literary Criticism

An ethologist shows man to be a gene machine whose world is one of savage competition and deceit

The Meanings of the Gene

Author: Celeste Michelle Condit
Publisher: Univ of Wisconsin Press
ISBN: 0299163644
Release Date: 1999
Genre: Medical

The Meanings of the Gene is a compelling look at societal hopes and fears about genetics in the course of the twentieth century. The work of scientists and doctors in advancing genetic research and its applications has been accompanied by plenty of discussion in the popular press—from Good Housekeeping and Forbes to Ms. and the Congressional Record—about such topics as eugenics, sterilization, DNA, genetic counseling, and sex selection. By demonstrating the role of rhetoric and ideology in public discussions about genetics, Condit raises the controversial question, Who shapes decisions about genetic research and its consequences for humans—scientists, or the public? Analyzing hundreds of stories from American magazines—and, later, television news—from the 1910s to the 1990s, Condit identifies three central and enduring public worries about genetics: that genes are deterministic arbiters of human fate; that genetics research can be used for discriminatory ends; and that advances in genetics encourage perfectionistic thinking about our children. Other key public concerns that Condit highlights are the complexity of genetic decision-making and potential for invasion of privacy; conflict over the human genetic code and experimentation with DNA; and family genetics and reproductive decisions. Her analysis reveals a persistent debate in the popular media between themes of genetic determinism (such as eugenics) and more egalitarian views that place genes within the complexity of biological and social life. The Meanings of the Gene offers an insightful view of our continuing efforts to grapple with our biological natures and to define what it means, and will mean in the future, to be human.

The Gene Wars

Author: Robert M. Cook-Deegan
Publisher: W. W. Norton & Company
ISBN: 0393035727
Release Date: 1994
Genre: Science

A look at the controversial Human Genome Project recounts the struggle to launch the multi-billion-dollar, ten- to twenty-year project and relies on primary documents gathered as events unfolded to unravel the tangled scientific and political threads of the story.

The Search for the Gene

Author: Bruce Wallace
Publisher: Cornell University Press
ISBN: 0801499674
Release Date: 1992
Genre: Science

From Gregor Mendel's experiments on garden peas to the mammoth Human Genome Project of today—how did we get where we are in the science of genetics? In this intriguing book, Bruce Wallace examines the concept of the gene and recounts the history of genetic research, providing a concise transition from genetics to modern molecular biology.