The year 2001 marked more than just the beginning of Stanley Kubrick's Space Odyssey, it marked the beginning of the genome era. That was the year scientists first read the 3 billion letters of DNA that make up the human genome. This was followed by a veritable Noah's Ark of genomesandmdash;sponges and worms, dogs and cows, rice and wheat, chimps and elephantsandmdash;180 creatures aboard so far. So what have we learned from all this? How has it changed the way we practise medicine, grow crops and breed livestock? What have we learned about evolution? These are the questions science writer and molecular biologist Elizabeth Finkel asked herself four years ago. To find the answers she travelled the science frontier from Botswana to Boston, from Warracknabeal to Mexico and tracked down scientists working in the field. Their stories, told here, paint the picture of what it means to be part of the genome generation. 'The Genome Generation is absolutely riveting. These tales from the frontier are a 'must read' for everyone who wishes to understand our pastandmdash;the logic of evolutionandmdash;or take a peep into our exciting future at the creation of 'super plants' through 'digital agriculture'.'andmdash;R.A. Mashelkar, CSIR Bhatnagar Fellow and India President, Global Research Alliance
Author: T. Ryan Gregory
Release Date: 2011-05-04
The Evolution of the Genome provides a much needed overview of genomic study through clear, detailed, expert-authored discussions of the key areas in genome biology. This includes the evolution of genome size, genomic parasites, gene and ancient genome duplications, polypoidy, comparative genomics, and the implications of these genome-level phenomena for evolutionary theory. In addition to reviewing the current state of knowledge of these fields in an accessible way, the various chapters also provide historical and conceptual background information, highlight the ways in which the critical questions are actually being studied, indicate some important areas for future research, and build bridges across traditional professional and taxonomic boundaries. The Evolution of the Genome will serve as a critical resource for graduate students, postdoctoral fellows, and established scientists alike who are interested in the issue of genome evolution in the broadest sense. Provides detailed, clearly written chapters authored by leading researchers in their respective fields Presents a much-needed overview of the historical and theoretical context of the various areas of genomic study Creates important links between topics in order to promote integration across subdisciplines, including descriptions of how each subject is actually studied Provides information specifically designed to be accessible to established researchers, postdoctoral fellows, and graduate students alike
The long-awaited story of the science, the business, the politics, the intrigue behind the scenes of the most ferocious competition in the history of modern science—the race to map the human genome. On May 10, 1998, biologist Craig Venter, director of the Institute for Genomic Research, announced that he was forming a private company that within three years would unravel the complete genetic code of human life—seven years before the projected finish of the U.S. government’s Human Genome Project. Venter hoped that by decoding the genome ahead of schedule, he would speed up the pace of biomedical research and save the lives of thousands of people. He also hoped to become very famous and very rich. Calling his company Celera (from the Latin for “speed”), he assembled a small group of scientists in an empty building in Rockville, Maryland, and set to work. At the same time, the leaders of the government program, under the direction of Francis Collins, head of the National Human Genome Research Institute at the National Institutes of Health, began to mobilize an unexpectedly unified effort to beat Venter to the prize—knowledge that had the potential to revolutionize medicine and society. The stage was set for one of the most thrilling—and important—dramas in the history of science. The Genome War is the definitive account of that drama—the race for the greatest prize biology has had to offer, told by a writer with exclusive access to Venter’s operation from start to finish. It is also the story of how one man’s ambition created a scientific Camelot where, for a moment, it seemed that the competing interests of pure science and commercial profit might be gloriously reconciled—and the national repercussions that resulted when that dream went awry. From the Hardcover edition.
Filled with stunning full-color illustrations, the editors of Nature present an authoritative guide to human genome sequencing, history's most significant discovery, that covers a vast array of information including genetics, basic biology, the key players, the project's landmark events, and its political, social, and scientific impact, and includes the full text of Nature's paper that divulged the human genome.
Author: Gary Zweiger
Publisher: McGraw Hill Professional
Release Date: 2002
"Captivating... hard to put down."Choice "A bracing insider's account of why gene structure matters to science and commerce."American Scientist How genomics is bringing biology into the Digital Age In this important book, a scientist gives us an inside account of the historic paradigm shift under way in the life sciences as a result of the Human Genome Project and provides a philosophical framework in which to understand biology and medicine as information sciences. In a story told on many fascinating levels, Gary Zweiger introduces us to the visionaries who first understood genes as information carriers and chronicles how their early efforts led to the birth of the new science of genomics. He provides insights into the uneasy collaboration of private, government, and academic efforts, the role of the pharmaceutical companies, and the influence of venture capitalists on one of the most ambitious and potentially significant scientific undertakings in history. Most important, he explores the profound impact that the transducing of biological information into a digital format already has had on biological research and medicine, and the equally profound effect it is sure to have on our understanding of ourselves and all living creatures.
Author: Caleb E. Finch
Publisher: University of Chicago Press
Release Date: 1994-05-16
Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.
Author: Peter John Myler
Publisher: Horizon Scientific Press
Release Date: 2008
Leishmania is a vector-prone pathogenic parasite found in 88 countries worldwide and is the causative agent of leishmaniasis. The different Leishmania species infect macrophages and dendritic cells of the host immune system, causing symptoms that include disfiguring cutaneous and mucocutaneous lesions, widespread destruction of mucous membranes and visceral disease affecting the haemopoietic organs. The recent publication of the comlete gennome sequences of three different Leishmania species provides new insights into this leading pathogen. In this book, experts critically review the most important aspects of Leishmania research. Chapters are written from a molecular and genomic perspective and discuss in depth Leishmania-specific aspects of trypanosomatid biology and pathology. Topics include diagnosis and epidemiology, genome structure and content, regulation of gene expression, the Leishmania proteome, the Leishmania metabolome, Leishmania differentiation, interaction with the sand fly vector, drug discovery, drug resistance, and much more.
Author: Julia E. Richards
Publisher: Academic Press
Release Date: 2005
This second edition of a very successful text reflects the tremendous pace of human genetics research and the demands that it places on society to understand and absorb its basic implications. The human genome has now been officially mapped and the cloning of animals is becoming a commonplace scientific discussion on the evening news. Join authors Julia Richards and Scott Hawley as they examine the biological foundations of humanity, looking at the science behind the sensation and the current and potential impact of the study of the genome on our society. The Human Genome, Second Edition is ideal for students and non-professionals, but will also serve as a fitting guide for the novice geneticist by providing a scientific, humanistic, and ethical frame of reference for a more detailed study of genetics. New in this edition: · 60% new material, including data from the Human Genome Project and the latest genetics and ethics discussions · Several new case studies and personal stories that bring the concepts of genetics and heredity to life · Simplified treatment of material for non-biology majors · New full-color art throughout the text · New co-author, Julia Richards, joins R. Scott Hawley in this revision
Author: David Barry
Publisher: Horizon Scientific Press
Release Date: 2007
Trypanosomes cause medically and economically severe diseases such as Sleeping Sickness and Chagas' Disease in humans and Nagana in cattle. They are also inherently interesting scientifically, being single-cell eukaryotes under constant, strong diversifying selection. The publication of the genome sequences of two key trypanosomes, Trypanosoma brucei and Trypanosoma cruzi, in 2005 has provided an exciting new resource to improve our understanding of the molecular and cellular biology of these important parasites and aid the development of new drugs and vaccines. The genome sequences, allied with useful genetic tools and easy molecular manipulation, will consolidate T. brucei as a eukaryotic model organism. As a model, it has the added advantage that studies in this area are directly applicable to understanding and prevention of disease. Research in this area has never been more exciting. In this book international experts review the contribution of trypanosome research to our understanding of eukaryote biology. Chapters are written from a molecular and genomic perspective and contain speculative models upon which to base future research efforts. Topics include: The genome of T. brucei, reverse and forward genetics, genetic exchange between trypanosomes, chromosome structure and dynamics, DNA replication, recombination and repair, transcription, post-transcriptional control of gene expression, cell structure, cell division and cell cycle, intracellular transport systems, cell surface architecture, antigenic variation, and comparative genomics of metabolism. The book provides an important resource summarising our current knowledge of trypanosome molecular and cellular biology.
Author: Betty Pace
Publisher: Imperial College Press
Release Date: 2007
The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook.
Author: Dan L. Lindsley
Publisher: Academic Press
Release Date: 2012-12-02
Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges All maps are reprinted as high-quality foldouts sturdily bound into the volume Maps may also be purchased separately in an eight-map packet, for laboratory and student use
Author: Ron Fridell
Publisher: Twenty-First Century Books
Release Date: 2005
Genre: Juvenile Nonfiction
The discovery and purpose of DNA, as well as what understanding the human genome means for the future, are competently outlined in this volume. Pros and cons of many ethical issues are covered--from stem cell research to designer babies.