Author: Tim Wu
Release Date: 2010-11-02
Genre: Business & Economics
A New Yorker and Fortune Best Book of the Year Analyzing the strategic maneuvers of today’s great information powers–Apple, Google, and an eerily resurgent AT&T–Tim Wu uncovers a time-honored pattern in which invention begets industry and industry begets empire. It is easy to forget that every development in the history of the American information industry–from the telephone to radio to film–once existed in an open and chaotic marketplace inhabited by entrepreneurs and utopians, just as the Internet does today. Each of these, however, grew to be dominated by a monopolist or cartel. In this pathbreaking book, Tim Wu asks: will the Internet follow the same fate? Could the Web–the entire flow of American information–come to be ruled by a corporate leviathan in possession of "the master switch"? Here, Tim Wu shows how a battle royale for Internet’s future is brewing, and this is one war we dare not tune out.
The must-read summary of Tim Wu's book: “The Master Switch: The Rise and Fall of Information Empires”. This complete summary of "The Master Switch" by Tim Wu, a renowned professor of law, presents his argument that information technology started as an open playing field and then eventually became dominated by a big entity exercising monopoly. He states that the world’s information is now traveling in a single network; the Internet, therefore he says that great information powers are locked in a battle over the Internet’s future. Added-value of this summary: • Save time • Understand the potential fate of the Internet to an information empire • Expand your knowledge of business politics and information wars To learn more, read "The Master Switch" and discover how information empires are set to be locked into a battle for the Internet's future.
Master Switch explores the terrifying consequences of a breach of security that puts the United States forces and Israeli defenses at risk.General Jeff Weyland has overseen the top secret development of the PATRIOT missle system since its beginning. But during a crucial stage of testing, he makes the horrifying discovery that someone has infiltrated the system.With the Gulf War looming and the lives of American and Israeli citizens at stake, Weyland must find out who is responsible for the missile's failure. With the assistance of Suzy Morris, a Senate staffer, and two old army buddies--Fish, a computer programmer, and Billy, a CIA operative--Weyland sets out through a maze of murder, intrigue, and terrorism to discover who has the most to gain if the PATRIOT missile system fails, and who controls the Master Switch.
The functions of the brain that allow us to think, feel, move, and perceive the world are the result of an exchange of information within a network composed of millions of specialized cells called neurons and glia. Neurons use neurotransmitters and other extracellular messengers to communicate with each other, and to constantly update and re-organize their network of connections in a process known as neural plasticity. In order to respond to these extracellular signals, neurons are equipped with specialized receptors that can recognize a single neurotransmitter a bit like a lock would recognize a key. They do this by activating or inhibiting a class of specialized signaling proteins and second messengers. Typically, signaling proteins are themselves organized in networks or pathways in which they activate or inhibit each other in order to integrate the mass of information received by a single cell and to regulate the biological functions of this cell. As we can see, rather than simply being a network of neurons, the brain can be seen as a sort of “Russian doll” in which each neuron is at the same time a part of networks with other neurons and the receptacle of many networks composed of signaling proteins. Two individual genes encode two paralogous signaling proteins: Glycogen Synthase Kinase -3 alpha and beta (GSK-3a, GSK-3b), named for its ability to phosphorylate a key metabolic enzyme of glycogen synthesis, glycogen synthase. This unique “glamour and gloom” protein kinase, has been intriguing many researches for over 30 years by its unusual features, still unknown mechanisms of its activation, its regulation by multiple “key” intracellular pathways, and its capacity to influence the functions of many substrates. Since GSK-3 was discovered, there has been significant progress in elucidating its regulatory roles in the neuron and the structure and functions of the brain. Lithium has been used as a gold standard in the treatment of bipolar disorder for 60 years; and “GSK-3’s renaissance” in psychiatry began with the discovery of GSK-3 as lithium's intracellular target. Since then, GSK3 has been implicated in the pathogenesis of mood disorders, schizophrenia, Alzheimer’s disease, ADHD, multiple sclerosis, Fragile X syndrome and Huntington disease. Connections to these and other diseases has led over the last 10 years to the generation of multiple types of GSK-3 inhibitors as promising therapeutic treatments for the aforementioned pathological conditions. During last couple years new genetic models have been generated, including conventional and conditional mouse models, allowing the discovery of new roles of GSK-3 in the mechanism of neurotransmitter action, neurodevelopment, learning and memory formation, GSK-3’s gene - effect on mouse behavior, and other functions. Thus, GSK-3 has been well-established as an intracellular second messenger for several neurotransmitter systems, and as an important therapeutic target of mood stabilizers, antipsychotics and psychomimetic drugs. The proposed Specific Topic for Frontiers in Neuroscience will be focused on the latest advances from leading laboratories in this area, subdivided into 5 topics: (1) GSK-3 history, mechanism of regulation, substrate specificity and comparison between the brain function of two GSK-3 genes through new animal models and cell biology approaches; (2) role of GSK-3 in neurodevelopment and neuronal structure; (3) involvement of GSK-3 in synaptic functions, learning and memory, and in serotonin and dopamine pathways; (4) role of GSK-3 in neuroinflammation, and application to the pathogenesis of multiple sclerosis, AD, schizophrenia, Fragile X, brain tumors, stroke and bipolar disorder; (5) development of GSK-3 inhibitors and their application in psychiatry, including special discussion about the mechanism of lithium action.
Author: U. S. Navy
Release Date: 2009-10
Genre: Technology & Engineering
PLEASE NOTE: THIS IS VOLUME 2 OF 2. YOU MUST PURCHASE BOTH BOOKS TO HAVE A COMPLETE SET. Developed as both an air superiority fighter and a long-range naval interceptor, Grumman's F-14 Tomcat was the U.S. Navy's primary fighter from 1974 until 2006. Over 700 were built. The F-14 flew its first combat missions shortly after its initial deployment in late 1974, flying in support of the American withdrawal from Saigon. In 1981 it drew first blood, as two F-14s from VF-41 downed two Libyan Su-22s. The plane compiled a notable combat record for the United States in both Gulf Wars and NATO actions in Bosnia. Planes sold to the Shah of Iran prior to his ouster remain the last F-14s in active service, as the U.S. Navy retired it in October 2006. This F-14 pilot's flight operating handbook was originally produced by the U.S. Navy. It has been slightly reformatted but is reproduced here in its entirety. It provides a fascinating view inside the cockpit of one of history's great planes.
Author: Al Santini
Publisher: Cengage Learning
Release Date: 2003-07-01
Genre: Business & Economics
How things work, why we test objects as we do, and what the test instruments tell us are all part of the foundation for this new book on automotive electricity and electronics. Completely up-to-date coverage emphasizes the fundamentals of electronics, setting the stage for smooth progression through more advanced topics such as batteries, starting and charging systems, ignitions, and electrical accessories. Testing is accomplished with common shop tools as well as highly technical equipment. Each chapter is written in a clear and concise fashion that is easy to follow, with current J1930 terminology incorporated throughout.
Author: Periscope Film Com
Release Date: 2006-04
The Consolidated B-24 Liberator first saw combat in June of 1942, making a daring raid into Nazi-occupied Romania to bomb the oil fields at Ploesti. Nearly 18,500 Liberators were built during the war years, making it by far the most-produced American combat aircraft. It served in many roles beyond heavy bomber, transport, and anti-submarine patrol, and flew in Africa, Europe, India, the Atlantic, India and the Pacific Theatre. Originally printed by the United States Army Air Force in 1942, the B-24 Liberator Pilot's Flight Operating Manual taught pilots everything they needed to know before entering the cockpit. Originally classified "Restricted," the manual was declassified long ago and is here reprinted in book form. This affordable facsimile has been reformatted, and color images appear as black and white. Care has been taken however to preserve the integrity of the text.
Author: David E. Mulcahy
Publisher: McGraw-Hill Professional Publishing
Release Date: 1999
Genre: Technology & Engineering
Your hands-on guide to materials handling and product movement methods for today's competitive facilities. With your staff, let this book show you how to dramatically improve the movement of materials in any warehouse, distribution, or manufacturing facility. This book will introduce you to the latest methods for designing, organizing, operating, and maintaining a state-of-the-art materials handling/product movement system. You'll learn about horizontal and vertical transportation techniques for items of all sizes--and get full details on inventory control...identification systems...cost estimates...site selection...product security...the use of consultants...and much more. This essential logistics tool features: insights and tips from plant and warehouse pros that will make your materials handling operations more efficient and cost effective; scores of illustrations, forms, and tables to assist you in developing product movement strategies that can be implemented immediately; complete information on the requirements of manual, mechanized, and automated systems.
Author: Roland Droh
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
R. Droh Ladies and gentlemen. dear friends and colleagues. we welcome you very cordially to our symposium "Innovations in Management and Technic and Pharmacol ogy". We are very glad that you have come to Liidenscheid and we do hope that our programme will fulfil your expectations. We decided to hold this symposium, because it is getting more and more dif ficult to select innovations at international congresses around the world which are important for our clinical work. Now and in the future our intention is to present the actual state of technology. management and pharmacology. We would be very glad to receive your suggestions for further symposia. The industry has the same problems as we have. They do not only have to search for those things which can be realized and which are desirable, but also for those things which can be sold. But the industry must also be stimulated by the inventors and by the users, so we want to bring together the industry, the physicians and the inventors for fruitful discussions. And we hope that in the fu ture the industry will provide us more quickly with those technical and organiz ational aids that we need. We want the indu~try no longer running behind the market but heading the market. At present too many interesting developments are killed by so-called market analysis, in the beliefing that such analysis can always prove what cannot be sold. In anaesthesia many companies are always busy with the same product.