"Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism. Providing this physical chemistry and biochemical foundation is The "Molecules of Life," a new undergraduate textbook for undergraduate students majoring in biology or pre-med. It deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena"--Provided by publisher.
The Molecules of Life is a textbook with a new approach to physical chemistry for the life sciences. Written for undergraduates majoring in biology or health sciences, it integrates fundamental concepts in thermodynamics and kinetics with an introduction to biological mechanism at the level of molecular structure.
"Key to making future advances in the areas of biochemistry and molecular medicine is a new generation of molecular biologists and biochemists who are able to harness the tools and insights of physics and chemistry to exploit the emergence of genomic and systems-level information in biology.The basic ideas of energy, entropy, equilibrium thermodynamics, transport processes and reaction kinetics are closely related to exciting issues in contemporary biology, such as protein folding, chaperones and prion diseases, DNA polymerase and ribosome fidelity, DNA recognition, drug design, signal transduction, ion channel function, motor protein action and the versatility of enzyme mechanism. Providing this physical chemistry and biochemical foundation is The "Molecules of Life", a new undergraduate textbook for undergraduate students majoring in biology or pre-med. It deepens our understanding of how life functions by illuminating the physical principles underpinning biological phenomena"--Provided by publisher.
Author: Bruce Alberts
Publisher: Garland Science
Release Date: 2017-08-07
As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
Author: Douglas Barrick
Publisher: CRC Press
Release Date: 2017-09-11
"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus.... the ample problems and tutorials throughout are much appreciated." –Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago "Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels." –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University "a masterful?tour de force.... Barrick's rigor and scholarship come through in every chapter." –Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
Author: Alan Fersht
Publisher: World Scientific
Release Date: 2017-06-28
This book is a guide for advanced undergraduates, post-graduates and researchers to the fundamental principles in studying kinetics and mechanism of processes concerning proteins. It provides a rare broad overview that concentrates on fundamental principles and understanding underlying the physics and chemistry. It is a single author text by someone who has direct experience in all of the areas covered.
The observation and manipulation of individual molecules is one of the most exciting developments in modern molecular science. Single Molecule Science: Physical Principles and Models provides an introduction to the mathematical tools and physical theories needed to understand, explain, and model single-molecule observations. This book explains the physical principles underlying the major classes of single-molecule experiments such as fluorescence measurements, force-probe spectroscopy, and nanopore experiments. It provides the framework needed to understand single-molecule phenomena by introducing all the relevant mathematical and physical concepts, and then discussing various approaches to the problem of interpreting single-molecule data. The essential concepts used throughout this book are explained in the appendices and the text does not assume any background beyond undergraduate chemistry, physics, and calculus. Every effort has been made to keep the presentation self-contained and derive results starting from a limited set of fundamentals, such as several simple models of molecular dynamics and the laws of probability. The result is a book that develops essential concepts in a simple yet rigorous way and in a manner that is accessible to a broad audience.
Author: David Sheehan
Publisher: John Wiley & Sons
Release Date: 2013-04-30
"As will be seen, there is not much missing here. I thought that the sections were well balanced, with rarely too much or too little on a given topic...This is a text to be welcomed by both teachers and students." BIOCHEMISTRY & MOLECULAR BIOLOGY EDUCATION (on the first edition) The second edition of this successful textbook explains the basic principles behind the key techniques currently used in the modern biochemical laboratory and describes the pros and cons of each technique and compares one to another. It is non-mathematical, comprehensive and approachable for students who are not physical chemists. A major update of this comprehensive, accessible introduction to physical biochemistry. Includes two new chapters on proteomics and bioinformatics. Introduces experimental approaches with a minimum of mathematics and numerous practical examples. Provides a bibliography at the end of each chapter. Written by an author with many years teaching and research experience, this text is a must-have for students of biochemistry, biophysics, molecular and life sciences and food science.
Author: Nicholas C. Price
Publisher: Oxford University Press on Demand
Release Date: 2001
What use is physical chemistry to the student of biochemistry and biology? This central question is answered in this book mainly through the use of worked examples and problems. The book starts by introducing the laws of thermodynamics, and then uses these laws to derive the equations relevant to the student in dealing with chemical equilibria (including the binding of small molecules to proteins), properties of solutions, acids and bases, and oxidation-reduction processes. The student is thus shown how a knowledge of thermodynamic qualities makes it possible to predict whether, and how, a reaction will proceed. Thermodynamics, however, gives no information about how fast a reaction will happen. The study of the rates at which processes occur (kinetics) forms the second main theme of the book. This section poses and answers questions such as `how is the rate of a reaction affected by temperature, pH, ionic strength, and the nature of the reactants? These same ideas are then shown to be useful in the study of enzyme-catalysed reactions.
Author: C. A. Trapp
Release Date: 2011
Genre: Chemistry, Physical and theoretical
The Solutions Manual to accompany Physical Chemistry for the Life Sciences 2e contains fully-worked solutions to all end-of-chapter discussion questions and exercises featured in the book. The manual provides helpful comments and friendly advice to aid understanding. It is also a valuableresource for any lecturer who wishes to use the extensive selection of exercises featured in the text to support either formative or summative assessment, and wants labour-saving, ready access to the full solutions to these questions.
Author: Trace Jordan
Release Date: 2017-03-15
Chemistry: The Molecules of Life is the only textbook for non-majors that focuses on the fundamental chemistry of biological molecules and everyday life. It uses the chemistry of life to introduce, explain, and apply chemical principles. Each chapter begins with a framing question to stimulatestudents' interest. Many framing questions are pertinent to students' health, whereas others address foundational scientific topics. Scientific content in each chapter is introduced on a "need-to-know" basis that is related to the framing question. By the end of the chapter, students will be able toanswer the question using the chemical concepts they have learned.Chemistry: The Molecules of Life is designed for students who have a variety of academic and career interests, not all of which necessarily align with the sciences or health professions. Its authors believe that all undergraduate students - not just science majors - need to be educated aboutscientific knowledge and reasoning in order to make informed decisions about their personal well-being and important societal issues. Have you ever thought about how antibiotic medications work, or why it is important to take the entire dose that the doctor prescribed? Many of us also take a vitaminsupplement, often in the form of a daily multivitamin. Do you know what roles these vitamins play in our body, or why the recommended daily dose for some vitamins is much lower than for others? Does the federal government regulate vitamin supplements with the same scrutiny that it applies topharmaceuticals? Chemistry: The Molecules of Life examines relevant topics such as these and many more.Scientific knowledge is constantly advancing. Almost daily, the media reports on a new scientific discovery, a new interpretation of what foods or activities are good or bad for us, or the societal impact of a new medical breakthrough. Given this rapid progress, science cannot be presented as acollection of facts to be memorized. After a short time, even the most current scientific knowledge becomes outdated. Instead, students need to understand how scientists investigate the natural world-the methods they use, the evidence they generate, and the conclusions they make based on thatevidence. For this reason, each chapter of Chemistry: The Molecules of Life describes examples of scientific discovery. By analyzing these case studies, students will develop the critical thinking skills necessary to thoughtfully evaluate scientific information that is presented in the news media orobtained from other sources.
Author: Jenny Gu
Publisher: John Wiley & Sons
Release Date: 2011-09-20
Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: "This book is a gold mine of fundamental and practical information in an area not previously well represented in book form." —Biochemistry and Molecular Education "... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students." —BAMBED "...a useful and timely summary of a rapidly expanding field." —Nature Structural Biology "...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." —Briefings in Bioinformatics