When Experiments Travel

Author: Adriana Petryna
Publisher: Princeton University Press
ISBN: 1400830826
Release Date: 2009-04-27
Genre: Social Science

The phenomenal growth of global pharmaceutical sales and the quest for innovation are driving an unprecedented search for human test subjects, particularly in middle- and low-income countries. Our hope for medical progress increasingly depends on the willingness of the world's poor to participate in clinical drug trials. While these experiments often provide those in need with vital and previously unattainable medical resources, the outsourcing and offshoring of trials also create new problems. In this groundbreaking book, anthropologist Adriana Petryna takes us deep into the clinical trials industry as it brings together players separated by vast economic and cultural differences. Moving between corporate and scientific offices in the United States and research and public health sites in Poland and Brazil, When Experiments Travel documents the complex ways that commercial medical science, with all its benefits and risks, is being integrated into local health systems and emerging drug markets. Providing a unique perspective on globalized clinical trials, When Experiments Travel raises central questions: Are such trials exploitative or are they social goods? How are experiments controlled and how is drug safety ensured? And do these experiments help or harm public health in the countries where they are conducted? Empirically rich and theoretically innovative, the book shows that neither the language of coercion nor that of rational choice fully captures the range of situations and value systems at work in medical experiments today. When Experiments Travel challenges conventional understandings of the ethics and politics of transnational science and changes the way we think about global medicine and the new infrastructures of our lives.

When Experiments Travel

Author: Adriana Petryna
Publisher: Princeton University Press
ISBN: 0691126577
Release Date: 2009-05-17
Genre: Social Science

The phenomenal growth of global pharmaceutical sales and the quest for innovation are driving an unprecedented search for human test subjects, particularly in middle- and low-income countries. Our hope for medical progress increasingly depends on the willingness of the world's poor to participate in clinical drug trials. While these experiments often provide those in need with vital and previously unattainable medical resources, the outsourcing and offshoring of trials also create new problems. In this groundbreaking book, anthropologist Adriana Petryna takes us deep into the clinical trials industry as it brings together players separated by vast economic and cultural differences. Moving between corporate and scientific offices in the United States and research and public health sites in Poland and Brazil, When Experiments Travel documents the complex ways that commercial medical science, with all its benefits and risks, is being integrated into local health systems and emerging drug markets. Providing a unique perspective on globalized clinical trials, When Experiments Travel raises central questions: Are such trials exploitative or are they social goods? How are experiments controlled and how is drug safety ensured? And do these experiments help or harm public health in the countries where they are conducted? Empirically rich and theoretically innovative, the book shows that neither the language of coercion nor that of rational choice fully captures the range of situations and value systems at work in medical experiments today. When Experiments Travel challenges conventional understandings of the ethics and politics of transnational science and changes the way we think about global medicine and the new infrastructures of our lives.

When People Come First

Author: João Biehl
Publisher: Princeton University Press
ISBN: 9781400846801
Release Date: 2013-07-07
Genre: Social Science

When People Come First critically assesses the expanding field of global health. It brings together an international and interdisciplinary group of scholars to address the medical, social, political, and economic dimensions of the global health enterprise through vivid case studies and bold conceptual work. The book demonstrates the crucial role of ethnography as an empirical lantern in global health, arguing for a more comprehensive, people-centered approach. Topics include the limits of technological quick fixes in disease control, the moral economy of global health science, the unexpected effects of massive treatment rollouts in resource-poor contexts, and how right-to-health activism coalesces with the increased influence of the pharmaceutical industry on health care. The contributors explore the altered landscapes left behind after programs scale up, break down, or move on. We learn that disease is really never just one thing, technology delivery does not equate with care, and biology and technology interact in ways we cannot always predict. The most effective solutions may well be found in people themselves, who consistently exceed the projections of experts and the medical-scientific, political, and humanitarian frameworks in which they are cast. When People Come First sets a new research agenda in global health and social theory and challenges us to rethink the relationships between care, rights, health, and economic futures.

Global Pharmaceuticals

Author: Adriana Petryna
Publisher: Duke University Press
ISBN: 082233741X
Release Date: 2006-03-15
Genre: Business & Economics

DIVAnthropological study of the globalization of pharmaceuticals and its effects on local cultures, health, and economics./div

Life Exposed

Author: Adriana Petryna
Publisher: Princeton University Press
ISBN: 9781400845095
Release Date: 2013-03-20
Genre: Social Science

On April 26, 1986, Unit Four of the Chernobyl nuclear reactor exploded in then Soviet Ukraine. More than 3.5 million people in Ukraine alone, not to mention many citizens of surrounding countries, are still suffering the effects. Life Exposed is the first book to comprehensively examine the vexed political, scientific, and social circumstances that followed the disaster. Tracing the story from an initial lack of disclosure to post-Soviet democratizing attempts to compensate sufferers, Adriana Petryna uses anthropological tools to take us into a world whose social realities are far more immediate and stark than those described by policymakers and scientists. She asks: What happens to politics when state officials fail to inform their fellow citizens of real threats to life? What are the moral and political consequences of remedies available in the wake of technological disasters? Through extensive research in state institutions, clinics, laboratories, and with affected families and workers of the so-called Zone, Petryna illustrates how the event and its aftermath have not only shaped the course of an independent nation but have made health a negotiated realm of entitlement. She tracks the emergence of a "biological citizenship" in which assaults on health become the coinage through which sufferers stake claims for biomedical resources, social equity, and human rights. Life Exposed provides an anthropological framework for understanding the politics of emergent democracies, the nature of citizenship claims, and everyday forms of survival as they are interwoven with the profound changes that accompanied the collapse of the Soviet Union.

The Republic of Therapy

Author: Vinh-Kim Nguyen
Publisher: Duke University Press
ISBN: 9780822393504
Release Date: 2010-10-11
Genre: Social Science

The Republic of Therapy tells the story of the global response to the HIV epidemic from the perspective of community organizers, activists, and people living with HIV in West Africa. Drawing on his experiences as a physician and anthropologist in Burkina Faso and Côte d’Ivoire, Vinh-Kim Nguyen focuses on the period between 1994, when effective antiretroviral treatments for HIV were discovered, and 2000, when the global health community acknowledged a right to treatment, making the drugs more available. During the intervening years, when antiretrovirals were scarce in Africa, triage decisions were made determining who would receive lifesaving treatment. Nguyen explains how those decisions altered social relations in West Africa. In 1994, anxious to “break the silence” and “put a face to the epidemic,” international agencies unwittingly created a market in which stories about being HIV positive could be bartered for access to limited medical resources. Being able to talk about oneself became a matter of life or death. Tracing the cultural and political logic of triage back to colonial classification systems, Nguyen shows how it persists in contemporary attempts to design, fund, and implement mass treatment programs in the developing world. He argues that as an enactment of decisions about who may live, triage constitutes a partial, mobile form of sovereignty: what might be called therapeutic sovereignty.

Taking the Medicine

Author: Druin Burch
Publisher: Random House
ISBN: 9781407021225
Release Date: 2009-01-15
Genre: Family & Relationships

Doctors and patients alike trust the medical profession and its therapeutic powers; yet this trust has often been misplaced. Whether prescribing opium or thalidomide, aspirin or antidepressants, doctors have persistently failed to test their favourite ideas - often with catastrophic results. From revolutionary America to Nazi Germany and modern big-pharmaceuticals, this is the unexpected story of just how bad medicine has been, and of its remarkably recent effort to improve. It is the history of well-meaning doctors misled by intuition, of the startling human cost of their mistakes and of the exceptional individuals who have helped make things better. Alarming and optimistic, Taking the Medicine is essential reading for anyone interested in how and why to trust the pills they swallow.

The Professional Guinea Pig

Author: Roberto Abadie
Publisher: Duke University Press
ISBN: 9780822393245
Release Date: 2010-07-09
Genre: Social Science

The Professional Guinea Pig documents the emergence of the professional research subject in Phase I clinical trials testing the safety of drugs in development. Until the mid-1970s Phase I trials were conducted on prisoners. After that practice was outlawed, the pharmaceutical industry needed a replacement population and began to aggressively recruit healthy, paid subjects, some of whom came to depend on the income, earning their living by continuously taking part in these trials. Drawing on ethnographic research among self-identified “professional guinea pigs” in Philadelphia, Roberto Abadie examines their experiences and views on the conduct of the trials and the risks they assume by participating. Some of the research subjects he met had taken part in more than eighty Phase I trials. While the professional guinea pigs tended to believe that most clinical trials pose only a moderate health risk, Abadie contends that the hazards presented by continuous participation, such as exposure to potentially dangerous drug interactions, are discounted or ignored by research subjects in need of money. The risks to professional guinea pigs are also disregarded by the pharmaceutical industry, which has become dependent on the routine participation of experienced research subjects. Arguing that financial incentives compromise the ethical imperative for informed consent to be freely given by clinical-trials subjects, Abadie confirms the need to reform policies regulating the participation of paid subjects in Phase I clinical trials.

Guinea Pig Zero

Author: Robert Helms
Publisher: Garrett County Press
ISBN: 9781891053283
Release Date: 2005-02-08
Genre: Biography & Autobiography

From first person accounts of pharmaceutical studies gone bad to intricate medical histories, Guinea Pig Zero provides a fascinating look at the people who sell their bodies to science. While the book provides advice to present-day research subjects (by rating research clinics), the book also provides context by investigating the history and ethics behind this important, but little-known medical industry.

Wombs in Labor

Author: Amrita Pande
Publisher: Columbia University Press
ISBN: 9780231169912
Release Date: 2014-09-30
Genre: Social Science

Surrogacy is IndiaÕs new form of outsourcing, as couples from all over the world hire Indian women to bear their children for a fraction of the cost of surrogacy elsewhere with little to no government oversight or regulation. In the first detailed ethnography of IndiaÕs surrogacy industry, Amrita Pande visits clinics and hostels and speaks with surrogates and their families, clients, doctors, brokers, and hostel matrons in order to shed light on this burgeoning business and the experiences of the laborers within it. From recruitment to training to delivery, PandeÕs research focuses on how reproduction meets production in surrogacy and how this reflects characteristics of IndiaÕs larger labor system. PandeÕs interviews prove surrogates are more than victims of disciplinary power, and she examines the strategies they deploy to retain control over their bodies and reproductive futures. While some women are coerced into the business by their families, others negotiate with clients and their clinics to gain access to technologies and networks otherwise closed to them. As surrogates, the women Pande meets get to know and make the most of advanced medical discoveries. They traverse borders and straddle relationships that test the boundaries of race, class, religion, and nationality. Those who focus on the inherent inequalities of IndiaÕs surrogacy industry believe the practice should be either banned or strictly regulated. Pande instead advocates for a better understanding of this complex labor market, envisioning an international model of fair-trade surrogacy founded on openness and transparency in all business, medical, and emotional exchanges.

Medical Apartheid

Author: Harriet A. Washington
Publisher: Anchor
ISBN: 076792939X
Release Date: 2008-01-08
Genre: History

From the era of slavery to the present day, the first full history of black America’s shocking mistreatment as unwilling and unwitting experimental subjects at the hands of the medical establishment. Medical Apartheid is the first and only comprehensive history of medical experimentation on African Americans. Starting with the earliest encounters between black Americans and Western medical researchers and the racist pseudoscience that resulted, it details the ways both slaves and freedmen were used in hospitals for experiments conducted without their knowledge—a tradition that continues today within some black populations. It reveals how blacks have historically been prey to grave-robbing as well as unauthorized autopsies and dissections. Moving into the twentieth century, it shows how the pseudoscience of eugenics and social Darwinism was used to justify experimental exploitation and shoddy medical treatment of blacks, and the view that they were biologically inferior, oversexed, and unfit for adult responsibilities. Shocking new details about the government’s notorious Tuskegee experiment are revealed, as are similar, less-well-known medical atrocities conducted by the government, the armed forces, prisons, and private institutions. The product of years of prodigious research into medical journals and experimental reports long undisturbed, Medical Apartheid reveals the hidden underbelly of scientific research and makes possible, for the first time, an understanding of the roots of the African American health deficit. At last, it provides the fullest possible context for comprehending the behavioral fallout that has caused black Americans to view researchers—and indeed the whole medical establishment—with such deep distrust. No one concerned with issues of public health and racial justice can afford not to read Medical Apartheid, a masterful book that will stir up both controversy and long-needed debate.

Introduction to Global Politics

Author: Steve Lamy
Publisher: Oxford University Press
ISBN: 9780190299798
Release Date: 2016-07-20
Genre: Geopolitics

Introduction to Global Politics, Fourth Edition, provides students with a current, engaging, and non-U.S. perspective on global politics. It shows students how to analyze global political events using theoretical approaches-both mainstream and alternative-and emphasizes non-state actors more than any other global politics text. Chapter-by-Chapter Revisions Chapter 1: Introduction to Global Politics -Expanded theoretical coverage introduces students to the three theoretical traditions in international relations theory: Machiavellian, Grotian, and Kantian -New Case Study: "Global Production and the iPhone" Chapter 2: The Evolution of Global Politics -Revised chapter-opening vignette addresses the goals of nation-states for survival and influence in the global system and how critical trends, such as the diffusion of power and increasing demands for vital resources, influence such goals -Expanded coverage of US-Cuba relations addresses the restoration of diplomatic ties -Further examination of the war on terrorism, including the completion of NATO's International Security Assistance Force mission in Afghanistan and its subsequent transition to the ongoing Resolute Support Mission -Updated Global Perspective "Perception, Continuity, and Change After January 20, 2009" addresses the continuing course of the Arab Spring -Updated statistics and graphics include "Estimated Global Nuclear Warheads, as of 2015," and "Number of Wars in Progress Since 1950" Chapter 3: Realism, Liberalism, and Critical Theories -Elimination of overlapping content between Chapter 3 and the first two introductory chapters, effectively streamlining the chapter and bringing its objectives of defining and describing the origins of IR theories, as well as explaining the relation among the levels of analysis and the different variations of the five schools of thought, into clearer focus -The latest on the most pertinent international relations matters including how world leaders should deal with extremist networks like the Islamic State Chapter 4: Making Foreign Policy -Further coverage and analysis of the UN Framework Convention on Climate Change, including the goals of the 2015 Paris Climate Change Conference -Expanded discussion of fragile states, including updates to the Fragile State Index -Discussion of foreign policy evaluation has been expanded to include criticism of the CIA's detention and treatment of prisoners taken in the wars in Iraq and Afghanistan -Additional examples of NGO influence on human rights (i.e. Human Rights Watch pressuring the Chinese government to abolish its re-education through labor detention system) -Updated statistics and graphics include "Top Ten Foreign Aid Donors" and the addition of a new figure "Share of World Military Expenditures of the 15 States with the Highest Expenditure" Chapter 5: Global and Regional Governance -Revised chapter-opening vignette addresses the impact of the Tunisian National Dialogue as a civil society organization and winner of the Nobel Peace Prize -Updated examples of venture philanthropy include Facebook co-founder and CEO Mark Zuckerberg's pledge to donate 99 percent of his wealth -Updated Case Study "A Global Campaign: The Baby Milk Advocacy Network" includes recent statistics from the World Health Organization. -Updated statistics and graphics include "INGO Growth Continues" and "Distribution of Think Tanks in the World" Chapter 6: Global Security, Military Power, and Terrorism -Updated information on conflicts including the Syrian civil war, the rise of the Islamic State and their goal to establish an Islamic Caliphate, and the UN peacekeeping mission in the Central African Republic to prevent civil wars and sectarian conflicts -Condensed coverage of mainstream and critical approaches to security in order to eliminate overlapping content found in Chapter 3: Realism, Liberalism, and Critical Theories -Added examples of the importance of collective action and reliance on international/regional organization (i.e. in the case of the 2015 Iran nuclear deal) -Expanded discussion of the effects of nuclear weapons and the idea that the international community is experiencing a new nuclear age in which weapons of mass destruction are used to secure strategic advantage -Updated Case Study "US Drone Warfare: A Robotic Revolution in Modern Combat" includes recent statistics on drone strikes -Updated information on the spread of jihadists, Al Qaeda, and ISIS and the geographical extent to which the Obama Administration (and future administrations) will have to go to find them -Updated statistics and graphics include "Arms Deliveries Worldwide," "Arms Transfer Agreements Worldwide"; the addition of two new figures: "Top Locations of Islamic State Twitter Users" and "Thirteen Years of Terror in Western Europe;" the addition of a new map: "Where ISIS Has Directed and Inspired Attacks;" and the addition of a table detailing the inter-actor relationship of those involved in the Syrian civil war Chapter 7: Human Rights and Human Security -Added information on the latest human rights crises (i.e. the refugee crisis, the Syrian civil war, and South Sudan) -New Case Study "A Failed Intervention" on the genocide occurring in Darfur -Updated statistics on current UN peacekeeping operations Chapter 8: Global Trade and Finance -Updated analysis on the current status of global economic interconnection (i.e. the role that governmental intervention has on the economy of their nation-states--including free markets, the impact of the slowdown of China's economy, and the effects of increasing global foreign direct investment) -New discussion of the Trans-Pacific Partnership and its subsequent implications as the largest regional trade agreement in history -Updated Theory in Practice "Contending Views of Capitalism" reflects recent changes in the Chinese economy and cyberwarfare tactics it uses against the US -Updated statistics and graphics include "Main Trading Nations," "Real GDP Growth," and the addition of a new graph "Holdings of US Treasury Securities" Chapter 9: Poverty, Development, and Hunger -Added discussion on the results of the Millennium Development Goals process (including an updated Progress Chart for UN Millennium Development Goals) and the UN's subsequent adoption of the new 2030 Agenda for Sustainable Development (illustrated by Sustainable Development Goals). -Updated discussions of world population statistics and estimated population growth projections, including new graphics "Projected World Population" and "Fastest Growing Populations" Chapter 10: Environmental Issues -Discussion of the latest environmental issues including the rising number of carbon emissions emitted on the planet, the effect climate change and environmental degradation are having as causes of major violence in regards to specific ethnic communities that compete for scarce resources, and how 2015 was the hottest year in recorded history -Added discussion of how climate change is the greatest challenge to economic and political stability across the world -Revised discussion of the latest Intergovernmental Panel on Climate Change report addresses the rise of global surface temperatures, the continued shrinking of sea ice, and how human influence correlates to climate change and increasing levels of greenhouse gas emissions in the atmosphere -Added information and analysis of the 2015 Paris Climate Change Conference, its outcomes, and the importance of adhering to pledges to curb emissions and keeping global temperature rises under 2 degrees Celsius; new concluding thoughts and analysis added as well -A revised table detailing "Recent Global Environmental Actions" focuses on events and actions of the past thirty years -Updated statistics and graphics include "Global Greenhouse Gas Emissions by Type of Gas," and two new graphics: "Number of Oils Spills between 1970-2015" and "Largest Producers of CO2 Emissions Worldwide."

Integrating Clinical Research into Epidemic Response

Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 9780309457767
Release Date: 2017-07-26
Genre: Medical

The 2014â€"2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014â€"2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Heath Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak. Integrating Clinical Research into Epidemic Response: The Ebola Experience assesses the value of the clinical trials held during the 2014â€"2015 epidemic and makes recommendations about how the conduct of trials could be improved in the context of a future international emerging or re-emerging infectious disease events.

A Practical Guide to Managing Clinical Trials

Author: JoAnn Pfeiffer
Publisher: CRC Press
ISBN: 9781315299778
Release Date: 2017-05-18
Genre: Medical

A Practical Guide to Managing Clinical Trials is a basic, comprehensive guide to conducting clinical trials. Designed for individuals working in research site operations, this user-friendly reference guides the reader through each step of the clinical trial process from site selection, to site set-up, subject recruitment, study visits, and to study close-out. Topics include staff roles/responsibilities/training, budget and contract review and management, subject study visits, data and document management, event reporting, research ethics, audits and inspections, consent processes, IRB, FDA regulations, and good clinical practices. Each chapter concludes with a review of key points and knowledge application. Unique to this book is "A View from India," a chapter-by-chapter comparison of clinical trial practices in India versus the U.S. Throughout the book and in Chapter 10, readers will glimpse some of the challenges and opportunities in the emerging and growing market of Indian clinical trials.